Fabrication of moxifloxacin HCl-loaded biodegradable chitosan nanoparticles for potential antibacterial and accelerated cutaneous wound healing efficacy / Misbah Hameed, Akhtar Rasul, Sumera Latif, Maria Rasool, Ghulam Abbas, Muhammad Irfan Siddique, Muhammad Khurram Waqas, Ikram Ullah Khan, Abid Mehmood Yousaf, Pervaiz Akhtar Shah
Abstract Aim This work aims to formulate topical hybrid gel containing chitosan-coated moxifloxacin (MXF) HCl nanoparticles (NPs) with enhanced antibacterial and healing activity. Methods MXF HCl NPs prepared by the ionic gelation method were loaded onto a hybrid chitosan carbomer gel. Size analysis of the prepared NPs was performed using SEM and Zeta-sizer. Further characterisation was done using Fourier transforms infra-red spectroscopy (FTIR), X-ray diffraction (XRD), and Thermogravimetric analysis (TGA). Prepared gel was evaluated for its in vitro drug release, biocompatibility, antibacterial activity, and stability studies under storage conditions. In-vivo wound healing was measured by observing percentage reduction in wound. Results NPs have 359 ± 79 nm mean particle size, 31.01 mV zeta potential with 0.008 polydispersity index (PD1), 63.5% drug entrapment and 83 ± 3.5% drug release at pH 5.5. Hybrid chitosan carbomer gel showed good biocompatibility, antibacterial, in-vivo wound healing properties and stable properties. Conclusions NP-loaded hybrid gel can be an effective treatment for acute and challenged topical wounds.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
|---|---|
| Enthalten in: |
Journal of microencapsulation - 39(2022), 1, Seite 37-48 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hameed, Misbah [VerfasserIn] |
|---|
| Links: |
FID Access [lizenzpflichtig] |
|---|
| Themen: |
Antibacterial |
|---|
| Umfang: |
1 Online-Ressource (12 p) |
|---|
| doi: |
10.1080/02652048.2021.2019332 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
KFL011131519 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | KFL011131519 | ||
| 003 | DE-627 | ||
| 005 | 20231109210022.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230609s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/02652048.2021.2019332 |2 doi | |
| 035 | |a (DE-627)KFL011131519 | ||
| 035 | |a (KFL)prod_LgpH_10.1080/02652048.2021.2019332 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 084 | |a PHARM |q DE-84 |2 fid | ||
| 100 | 1 | |a Hameed, Misbah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fabrication of moxifloxacin HCl-loaded biodegradable chitosan nanoparticles for potential antibacterial and accelerated cutaneous wound healing efficacy |c Misbah Hameed, Akhtar Rasul, Sumera Latif, Maria Rasool, Ghulam Abbas, Muhammad Irfan Siddique, Muhammad Khurram Waqas, Ikram Ullah Khan, Abid Mehmood Yousaf, Pervaiz Akhtar Shah |
| 264 | 1 | |c 2022 | |
| 300 | |a 1 Online-Ressource (12 p) | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Aim This work aims to formulate topical hybrid gel containing chitosan-coated moxifloxacin (MXF) HCl nanoparticles (NPs) with enhanced antibacterial and healing activity. Methods MXF HCl NPs prepared by the ionic gelation method were loaded onto a hybrid chitosan carbomer gel. Size analysis of the prepared NPs was performed using SEM and Zeta-sizer. Further characterisation was done using Fourier transforms infra-red spectroscopy (FTIR), X-ray diffraction (XRD), and Thermogravimetric analysis (TGA). Prepared gel was evaluated for its in vitro drug release, biocompatibility, antibacterial activity, and stability studies under storage conditions. In-vivo wound healing was measured by observing percentage reduction in wound. Results NPs have 359 ± 79 nm mean particle size, 31.01 mV zeta potential with 0.008 polydispersity index (PD1), 63.5% drug entrapment and 83 ± 3.5% drug release at pH 5.5. Hybrid chitosan carbomer gel showed good biocompatibility, antibacterial, in-vivo wound healing properties and stable properties. Conclusions NP-loaded hybrid gel can be an effective treatment for acute and challenged topical wounds | ||
| 653 | |a Moxifloxacin HCl | ||
| 653 | |a nanoparticles | ||
| 653 | |a chitosan | ||
| 653 | |a antibacterial | ||
| 653 | |a wound healing | ||
| 700 | 1 | |a Rasul, Akhtar |e verfasserin |4 aut | |
| 700 | 1 | |a Latif, Sumera |e verfasserin |4 aut | |
| 700 | 1 | |a Rasool, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Abbas, Ghulam |e verfasserin |4 aut | |
| 700 | 1 | |a Siddique, Muhammad Irfan |e verfasserin |4 aut | |
| 700 | 1 | |a Waqas, Muhammad Khurram |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Ikram Ullah |e verfasserin |4 aut | |
| 700 | 1 | |a Yousaf, Abid Mehmood |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Pervaiz Akhtar |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of microencapsulation |d Abingdon : Taylor & Francis Group, 1984 |g 39(2022), 1, Seite 37-48 |h Online-Ressource |w (DE-627)KFL000005967 |w (DE-600)1491079-2 |w (DE-576)079719244 |x 1464-5246 |7 nnns |
| 773 | 1 | 8 | |g volume:39 |g year:2022 |g number:1 |g pages:37-48 |
| 856 | 4 | 0 | |u http://pharmazie.proxy.fid-lizenzen.de/fid/tandf-ejournals-pharmazie/doi.org/10.1080/02652048.2021.2019332 |m X:KFL |x Resolving-System |y FID Access |z lizenzpflichtig |
| 912 | |a ZDB-1-TFE | ||
| 912 | |a GBV_KFL | ||
| 912 | |a FID-PHARM | ||
| 935 | |i IMPORT_0628_prod_LgpH_05 | ||
| 951 | |a AR | ||
| 952 | |d 39 |j 2022 |e 1 |h 37-48 | ||