Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials / Samvel B. Gasparyan, Elaine K. Kowalewski, Folke Folkvaljon, Olof Bengtsson, Joan Buenconsejo, John Adler, Gary G. Koch
ABSTRACT The win odds is a distribution-free method of comparing locations of distributions of two independent random variables. Introduced as a method for analyzing hierarchical composite endpoints, it is well suited to be used in the analysis of ordinal scale endpoints in COVID-19 clinical trials. For a single outcome, we provide power and sample size calculation formulas for the win odds test. We also provide an implementation of the win odds analysis method for a single ordinal outcome in a commonly used statistical software to make the win odds analysis fully reproducible.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
---|---|
Enthalten in: |
Journal of biopharmaceutical statistics - 31(2021), 6, Seite 765-787 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Gasparyan, Samvel B. [VerfasserIn] |
---|
Links: |
FID Access [lizenzpflichtig] |
---|
Themen: |
COVID-19 |
---|
Umfang: |
1 Online-Ressource (23 p) |
---|
doi: |
10.1080/10543406.2021.1968893 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
KFL011118571 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | KFL011118571 | ||
003 | DE-627 | ||
005 | 20230713210805.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230609s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/10543406.2021.1968893 |2 doi | |
035 | |a (DE-627)KFL011118571 | ||
035 | |a (KFL)prod_LgpH_10.1080/10543406.2021.1968893 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
084 | |a PHARM |q DE-84 |2 fid | ||
100 | 1 | |a Gasparyan, Samvel B. |e verfasserin |4 aut | |
245 | 1 | 0 | |a Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials |c Samvel B. Gasparyan, Elaine K. Kowalewski, Folke Folkvaljon, Olof Bengtsson, Joan Buenconsejo, John Adler, Gary G. Koch |
264 | 1 | |c 2021 | |
300 | |a 1 Online-Ressource (23 p) | ||
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a ABSTRACT The win odds is a distribution-free method of comparing locations of distributions of two independent random variables. Introduced as a method for analyzing hierarchical composite endpoints, it is well suited to be used in the analysis of ordinal scale endpoints in COVID-19 clinical trials. For a single outcome, we provide power and sample size calculation formulas for the win odds test. We also provide an implementation of the win odds analysis method for a single ordinal outcome in a commonly used statistical software to make the win odds analysis fully reproducible | ||
653 | |a Win odds | ||
653 | |a COVID-19 | ||
653 | |a power | ||
653 | |a sample size | ||
653 | |a effect size | ||
653 | |a number needed to treat | ||
653 | |a Mann-Whitney | ||
653 | |a Fligner-Policello | ||
653 | |a Somers’ D C/R | ||
653 | |a Wilcoxon rank-sum | ||
653 | |a SAS software | ||
700 | 1 | |a Kowalewski, Elaine K. |e verfasserin |4 aut | |
700 | 1 | |a Folkvaljon, Folke |e verfasserin |4 aut | |
700 | 1 | |a Bengtsson, Olof |e verfasserin |4 aut | |
700 | 1 | |a Buenconsejo, Joan |e verfasserin |4 aut | |
700 | 1 | |a Adler, John |e verfasserin |4 aut | |
700 | 1 | |a Koch, Gary G. |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of biopharmaceutical statistics |d Philadelphia, PA : Taylor & Francis, 1991 |g 31(2021), 6, Seite 765-787 |h Online-Ressource |w (DE-627)KFL000088641 |w (DE-600)2008925-9 |w (DE-576)27387828X |x 1520-5711 |7 nnns |
773 | 1 | 8 | |g volume:31 |g year:2021 |g number:6 |g pages:765-787 |
856 | 4 | 0 | |u http://pharmazie.proxy.fid-lizenzen.de/fid/tandf-ejournals-pharmazie/doi.org/10.1080/10543406.2021.1968893 |m X:KFL |x Resolving-System |y FID Access |z lizenzpflichtig |
912 | |a ZDB-1-TFE | ||
912 | |a GBV_KFL | ||
912 | |a FID-PHARM | ||
935 | |i IMPORT_0628_prod_LgpH_02 | ||
951 | |a AR | ||
952 | |d 31 |j 2021 |e 6 |h 765-787 |