Ternary system of sultamicillin tosylate with hydroxypropyl-β-cyclodextrin and L-arginine: susceptibility against methicillin-resistantStaphylococcus aureus / Marvin Bolibol, Gerard de Guzman, Liza Marie De Guzman
Aim:This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG).Materials & methods:The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC.Results:Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA.Conclusion:As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections. Aim: Materials & methods: ® Results: Conclusion: Graphical abstract Plain language summary Aim:In this study, the combined effects of sultamicillin tosylate (ST), hydroxypropyl-β-cyclodextrin (HP-βCD) and L-arginine (ARG) were investigated.Materials & methods:Combination of ST and HP-βCD with/without ARG were prepared through the kneading method. ST and its complexes were evaluated for antibacterial activity against methicillin-resistantStaphylococcus aureus(MRSA).Results:In comparison with ST, its complexes are easier to dissolve and have been shown to be more effective against MRSA.Conclusion:The physical and chemical characteristics of ST as well as its antibacterial efficacy against MRSA infections can be enhanced by combining ST with HP-βC and ARG. Aim: Materials & methods: Staphylococcus aureus Results: Conclusion.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
Erscheinungsort nicht ermittelbar: 2023 |
Enthalten in: |
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Sprache: |
Englisch |
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Beteiligte Personen: |
Bolibol, Marvin [VerfasserIn] |
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Links: |
FID Access [lizenzpflichtig] |
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Themen: |
Hydroxypropyl-β-cyclodextrin |
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Umfang: |
1 Online-Ressource (15 p) |
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doi: |
10.4155/tde-2022-0050 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
KFL01109768X |
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520 | |a Aim:This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG).Materials & methods:The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC.Results:Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA.Conclusion:As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections. Aim: Materials & methods: ® Results: Conclusion: Graphical abstract Plain language summary Aim:In this study, the combined effects of sultamicillin tosylate (ST), hydroxypropyl-β-cyclodextrin (HP-βCD) and L-arginine (ARG) were investigated.Materials & methods:Combination of ST and HP-βCD with/without ARG were prepared through the kneading method. ST and its complexes were evaluated for antibacterial activity against methicillin-resistantStaphylococcus aureus(MRSA).Results:In comparison with ST, its complexes are easier to dissolve and have been shown to be more effective against MRSA.Conclusion:The physical and chemical characteristics of ST as well as its antibacterial efficacy against MRSA infections can be enhanced by combining ST with HP-βC and ARG. Aim: Materials & methods: Staphylococcus aureus Results: Conclusion | ||
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