Optimization of folic acid Span 60-organogel to enhance itsin vitroandin vivophotoprotection: a comparative study / Eman S Shalaby, Samy I Shalaby
Aim:The acute effects of UV sunlight exposure were inflammation, erythema, and swelling. The present work aims to formulate a novel organogel preparation that can achieve efficient topical folic acid (FA) delivery to cure inflammation from acute exposure to UV sunlight.Methods:The organogels were prepared by direct melting and stirring on a magnetic stirrer. Photostability andin vivophotoprotection were investigated.Results:Optimized organogel showed more sustained release, more photostability, more effective antioxidant activity, higherin vitrosun protection factor, and greater extent of skin photoprotection from natural sunlight.Conclusion:The present results suggest optimized FA organogel as a promising formulation for effective delivery of FA to the skin maximizing it'sin vitroandin vivoperformance. Aim: Methods: in vivo Results: in vitro Conclusion: in vitro in vivo Graphical abstract Plain language summary Purpose:The present work aimed at selection of components of a novel organogel formulation which is able to achieve efficient controlled folic acid (FA) topical delivery to skin to effectively cure inflammation produced from acute exposure to natural sunlight. Organogels could effectively deliver lipophilic drugs in a more controlled manner. Selection of components of optimized organogel formulation would suggest enhancement in the antioxidant properties, photostability andin vivoperformance of FA.Methods:optimized organogel was prepared by incubating the vial containing components in a water bath for 40 min at 65°C till gain a clear solution to ensure their solubility then the vial is left to cool down to room temperature.Results:Optimized organogel showed higher spreadability and occlusion (F factor = 61.2) than traditional organogel. Optimized FA organogel showed more sustained release and photostability than traditional FA organogel. Optimized organogel and traditional organogel FTIR showed complete absence of drug peaks suggesting strong association of drug inside the formulations. Optimized FA organogel showed maximumin vitroandin vivoprotection from UV irradiation.Conclusion:Optimized FA organogel showed the most effective antioxidant, the highest value ofin vitrosun protection factor and the highest value for photo protection of skin from nature sunlight in thein vivostudies. All the present results suggesting optimized FA organogel as a promising formulation for effective safe delivery of FA to skin maximizing it'sin vitroandin vivoperformance. Purpose: in vivo Methods: Results: in vitro in vivo Conclusion: in vitro in vivo in vitro in vivo.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2023 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shalaby, Eman S [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Antioxidant |
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| Umfang: |
1 Online-Ressource (14 p) |
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| doi: |
10.4155/tde-2022-0048 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL011097655 |
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| 245 | 1 | 0 | |a Optimization of folic acid Span 60-organogel to enhance itsin vitroandin vivophotoprotection: a comparative study |c Eman S Shalaby, Samy I Shalaby |
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| 520 | |a Aim:The acute effects of UV sunlight exposure were inflammation, erythema, and swelling. The present work aims to formulate a novel organogel preparation that can achieve efficient topical folic acid (FA) delivery to cure inflammation from acute exposure to UV sunlight.Methods:The organogels were prepared by direct melting and stirring on a magnetic stirrer. Photostability andin vivophotoprotection were investigated.Results:Optimized organogel showed more sustained release, more photostability, more effective antioxidant activity, higherin vitrosun protection factor, and greater extent of skin photoprotection from natural sunlight.Conclusion:The present results suggest optimized FA organogel as a promising formulation for effective delivery of FA to the skin maximizing it'sin vitroandin vivoperformance. Aim: Methods: in vivo Results: in vitro Conclusion: in vitro in vivo Graphical abstract Plain language summary Purpose:The present work aimed at selection of components of a novel organogel formulation which is able to achieve efficient controlled folic acid (FA) topical delivery to skin to effectively cure inflammation produced from acute exposure to natural sunlight. Organogels could effectively deliver lipophilic drugs in a more controlled manner. Selection of components of optimized organogel formulation would suggest enhancement in the antioxidant properties, photostability andin vivoperformance of FA.Methods:optimized organogel was prepared by incubating the vial containing components in a water bath for 40 min at 65°C till gain a clear solution to ensure their solubility then the vial is left to cool down to room temperature.Results:Optimized organogel showed higher spreadability and occlusion (F factor = 61.2) than traditional organogel. Optimized FA organogel showed more sustained release and photostability than traditional FA organogel. Optimized organogel and traditional organogel FTIR showed complete absence of drug peaks suggesting strong association of drug inside the formulations. Optimized FA organogel showed maximumin vitroandin vivoprotection from UV irradiation.Conclusion:Optimized FA organogel showed the most effective antioxidant, the highest value ofin vitrosun protection factor and the highest value for photo protection of skin from nature sunlight in thein vivostudies. All the present results suggesting optimized FA organogel as a promising formulation for effective safe delivery of FA to skin maximizing it'sin vitroandin vivoperformance. Purpose: in vivo Methods: Results: in vitro in vivo Conclusion: in vitro in vivo in vitro in vivo | ||
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