Potentials and limitations of pharmaceutical and pharmacological applications of bile acids in hearing loss treatment / Michael Lewkowicz, Melissa Jones, Bozica Kovacevic, Corina Mihaela Ionescu, Susbin Raj Wagle, Thomas Foster, Momir Mikov, Armin Mooranian, Hani Al-Salami
Hearing loss is a worldwide epidemic, with approximately 1.5 billion people currently struggling with hearing-related conditions. Currently, the most wildly used and effective treatments for hearing loss are primarily focus on the use of hearing aids and cochlear implants. However, these have many limitations, highlighting the importance of developing a pharmacological solution that may be used to overcome barriers associated with such devices. Due to the challenges of delivering therapeutic agents to the inner ear, bile acids are being explored as potential drug excipients and permeation enhancers. This review, therefore, aims to explore the pathophysiology of hearing loss, the challenges in treatment and the manners in which bile acids could potentially aid in overcoming these challenges.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2023 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lewkowicz, Michael [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Bile acids |
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| Umfang: |
1 Online-Ressource (12 p) |
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| doi: |
10.4155/tde-2022-0033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL011097612 |
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| 520 | |a Hearing loss is a worldwide epidemic, with approximately 1.5 billion people currently struggling with hearing-related conditions. Currently, the most wildly used and effective treatments for hearing loss are primarily focus on the use of hearing aids and cochlear implants. However, these have many limitations, highlighting the importance of developing a pharmacological solution that may be used to overcome barriers associated with such devices. Due to the challenges of delivering therapeutic agents to the inner ear, bile acids are being explored as potential drug excipients and permeation enhancers. This review, therefore, aims to explore the pathophysiology of hearing loss, the challenges in treatment and the manners in which bile acids could potentially aid in overcoming these challenges | ||
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| 700 | 1 | |a Kovacevic, Bozica |e verfasserin |4 aut | |
| 700 | 1 | |a Ionescu, Corina Mihaela |e verfasserin |4 aut | |
| 700 | 1 | |a Wagle, Susbin Raj |e verfasserin |4 aut | |
| 700 | 1 | |a Foster, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Mikov, Momir |e verfasserin |4 aut | |
| 700 | 1 | |a Mooranian, Armin |e verfasserin |4 aut | |
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