Solid lipid nanoparticles loaded with curcumin: development andin vitrotoxicity against CT26 cells / Rayane Ganassin, Victor Carlos Mello da Silva, Victor Hugo Sousa Araujo, Giulia Rosa Tavares, Patrícia Bento da Silva, Paolin Rocio Cáceres-Vélez, Joaquin E Martínez Porcel, Mosar Corrêa Rodrigues, Patrizia Andreozzi, Richard Perosa Fernandes, Bruno Fonseca-Santos, Sergio Moya, Ricardo Bentes Azevedo, Marlus Chorilli, Luis Alexandre Muehlmann
Aim:To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs).Methods:A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cellsin vitrowas analyzed by confocal microscopy.Results:Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cellsin vitro.Conclusion:These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media. Aim: Methods: in vitro Results: in vitro Conclusion: Graphical abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2022 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ganassin, Rayane [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Cancer |
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| Umfang: |
1 Online-Ressource (13 p) |
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| doi: |
10.2217/nnm-2021-0229 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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KFL011096284 |
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| 245 | 1 | 0 | |a Solid lipid nanoparticles loaded with curcumin: development andin vitrotoxicity against CT26 cells |c Rayane Ganassin, Victor Carlos Mello da Silva, Victor Hugo Sousa Araujo, Giulia Rosa Tavares, Patrícia Bento da Silva, Paolin Rocio Cáceres-Vélez, Joaquin E Martínez Porcel, Mosar Corrêa Rodrigues, Patrizia Andreozzi, Richard Perosa Fernandes, Bruno Fonseca-Santos, Sergio Moya, Ricardo Bentes Azevedo, Marlus Chorilli, Luis Alexandre Muehlmann |
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| 520 | |a Aim:To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs).Methods:A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cellsin vitrowas analyzed by confocal microscopy.Results:Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cellsin vitro.Conclusion:These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media. Aim: Methods: in vitro Results: in vitro Conclusion: Graphical abstract | ||
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| 700 | 1 | |a da Silva, Victor Carlos Mello |e verfasserin |4 aut | |
| 700 | 1 | |a Araujo, Victor Hugo Sousa |e verfasserin |4 aut | |
| 700 | 1 | |a Tavares, Giulia Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva, Patrícia Bento |e verfasserin |4 aut | |
| 700 | 1 | |a Cáceres-Vélez, Paolin Rocio |e verfasserin |4 aut | |
| 700 | 1 | |a Porcel, Joaquin E Martínez |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Mosar Corrêa |e verfasserin |4 aut | |
| 700 | 1 | |a Andreozzi, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandes, Richard Perosa |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca-Santos, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Moya, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Azevedo, Ricardo Bentes |e verfasserin |4 aut | |
| 700 | 1 | |a Chorilli, Marlus |e verfasserin |4 aut | |
| 700 | 1 | |a Muehlmann, Luis Alexandre |e verfasserin |4 aut | |
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