Multifunctional nanocarriers of Fe3O4PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery / Phan Quoc Thong, Le Thi Thu Huong, Nguyen Dac Tu, Hoang Thi My Nhung, Lam Khanh, Do Hung Manh, Pham Hong Nam, Nguyen Xuan Phuc, Javier Alonso, Ju Qiao, Srinivas Sridhar, Ha Phuong Thu, Manh Huong Phan, Nguyen Thi Kim Thanh
Background:Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs.Methods:This study fabricated novel trifunctional MNPs of Fe3O4PLA-PEG for drug release, MRI and magnetic fluid hyperthermia.Result:The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity (r2 = 364.75 mM-1s-1). Thein vivostudy confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180.Conclusion:The nanocarrier has potential for drug release, cancer treatment monitoring and therapy. Background: Methods: 3 4 Result: r 2 -1 -1 in vivo Conclusion: Plain language summary In this study, the authors designed and fabricated novel magnetic trifunctional nanoparticles of Fe3O4@PLA-PEG. The 8.5 nm Fe3O4core was covered with the polymeric matrix of PLA-PEG to encapsulate an anticancer agent of curcumin at a content of about 11%. Curcumin release from the nanoparticles (NPs) could be controlled by applying a remote alternating magnetic field. The NPs enhanced MRI contrast, which allowed the authors to better distinguish the tumor and surroundings in MR images, which would help monitor treatment. The heat that NPs generated when applied to a field at low intensity could effectively reduce the tumor size in mice bearing sarcoma 180. The nanocarrier, therefore, has potential for cancer treatment monitoring and drug release conjuvant with magnetic hyperthermia therapy. 3 4 3 4 Graphical abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2023 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Thong, Phan Quoc [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
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| Umfang: |
1 Online-Ressource (17 p) |
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| doi: |
10.2217/nnm-2022-0070 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Multifunctional nanocarriers of Fe3O4PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery |c Phan Quoc Thong, Le Thi Thu Huong, Nguyen Dac Tu, Hoang Thi My Nhung, Lam Khanh, Do Hung Manh, Pham Hong Nam, Nguyen Xuan Phuc, Javier Alonso, Ju Qiao, Srinivas Sridhar, Ha Phuong Thu, Manh Huong Phan, Nguyen Thi Kim Thanh |
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| 520 | |a Background:Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs.Methods:This study fabricated novel trifunctional MNPs of Fe3O4PLA-PEG for drug release, MRI and magnetic fluid hyperthermia.Result:The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity (r2 = 364.75 mM-1s-1). Thein vivostudy confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180.Conclusion:The nanocarrier has potential for drug release, cancer treatment monitoring and therapy. Background: Methods: 3 4 Result: r 2 -1 -1 in vivo Conclusion: Plain language summary In this study, the authors designed and fabricated novel magnetic trifunctional nanoparticles of Fe3O4@PLA-PEG. The 8.5 nm Fe3O4core was covered with the polymeric matrix of PLA-PEG to encapsulate an anticancer agent of curcumin at a content of about 11%. Curcumin release from the nanoparticles (NPs) could be controlled by applying a remote alternating magnetic field. The NPs enhanced MRI contrast, which allowed the authors to better distinguish the tumor and surroundings in MR images, which would help monitor treatment. The heat that NPs generated when applied to a field at low intensity could effectively reduce the tumor size in mice bearing sarcoma 180. The nanocarrier, therefore, has potential for cancer treatment monitoring and drug release conjuvant with magnetic hyperthermia therapy. 3 4 3 4 Graphical abstract | ||
| 653 | |a curcumin | ||
| 653 | |a drug delivery | ||
| 653 | |a Fe3O4nanoparticles | ||
| 653 | |a hyperthermia | ||
| 653 | |a MRI | ||
| 700 | 1 | |a Thu Huong, Le Thi |e verfasserin |4 aut | |
| 700 | 1 | |a Tu, Nguyen Dac |e verfasserin |4 aut | |
| 700 | 1 | |a My Nhung, Hoang Thi |e verfasserin |4 aut | |
| 700 | 1 | |a Khanh, Lam |e verfasserin |4 aut | |
| 700 | 1 | |a Manh, Do Hung |e verfasserin |4 aut | |
| 700 | 1 | |a Nam, Pham Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Phuc, Nguyen Xuan |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Sridhar, Srinivas |e verfasserin |4 aut | |
| 700 | 1 | |a Thu, Ha Phuong |e verfasserin |4 aut | |
| 700 | 1 | |a Phan, Manh Huong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim Thanh, Nguyen Thi |e verfasserin |4 aut | |
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