Blood cell quantification on dry blood samples: toward patient-centric complete blood counts / Mikolaj Dobielewski, Janosch Hauser, Olof Beck, Göran Stemme, Niclas Roxhed
Background:Performing complete blood counts from patients' homes could have a transformative impact on e-based healthcare. Blood microsampling and sample drying are enabling elements for patient-centric healthcare. The aim of this study was to investigate the potential of dry blood samples for image-based cell quantification of red and white blood cells.Methods:A manual sample preparation method was developed and tested for image-based red and white blood cell counting.Results & conclusion:Dry blood samples enable image-based cell counting of red and white blood cells with a good correlation to gold standard hematology analyzer data (average coefficient of variation <6.5%; R2 >0.8) and resolve the basic morphology of white blood cell nuclei. The presented proof-of-principle study is a first step toward patient-centric complete blood counts. Background: Methods: Results & conclusion: 2.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2022 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dobielewski, Mikolaj [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Blood |
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| Umfang: |
1 Online-Ressource (9 p) |
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| doi: |
10.4155/bio-2022-0029 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL011092556 |
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| 100 | 1 | |a Dobielewski, Mikolaj |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Blood cell quantification on dry blood samples: toward patient-centric complete blood counts |c Mikolaj Dobielewski, Janosch Hauser, Olof Beck, Göran Stemme, Niclas Roxhed |
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| 520 | |a Background:Performing complete blood counts from patients' homes could have a transformative impact on e-based healthcare. Blood microsampling and sample drying are enabling elements for patient-centric healthcare. The aim of this study was to investigate the potential of dry blood samples for image-based cell quantification of red and white blood cells.Methods:A manual sample preparation method was developed and tested for image-based red and white blood cell counting.Results & conclusion:Dry blood samples enable image-based cell counting of red and white blood cells with a good correlation to gold standard hematology analyzer data (average coefficient of variation <6.5%; R2 >0.8) and resolve the basic morphology of white blood cell nuclei. The presented proof-of-principle study is a first step toward patient-centric complete blood counts. Background: Methods: Results & conclusion: 2 | ||
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| 700 | 1 | |a Beck, Olof |e verfasserin |4 aut | |
| 700 | 1 | |a Stemme, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Roxhed, Niclas |e verfasserin |4 aut | |
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