Dissolution profiles of fenbendazole from binary solid dispersions: a mathematical approach / María Elisa Melian, Cintia Alejandra Briones Nieva, Laura Domínguez, Elio Emilio Gonzo, Santiago Palma, José María Bermúdez
Aim:Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictablein vivoperformance.Materials & methods:Dissolution data of fenbendazole released from the SDs and the control physical mixtures were analyzed using the Lumped mathematical model to estimate the parameters of pharmaceutical relevance.Results:The fit data obtained by Lumped model showed that all SDs have a unique dissolution profile with an error of ±4.1% and an initial release rate 500-times higher than the pure drug, without incidence of drug/polymer ratio or polymer type.Conclusion:The Lumped model helped to understand that the main factor influencing the fenbendazole release was the type formulation (SD or physical mixture), regardless of the type or amount of polymer used. Aim: in vivo Materials & methods: Results: Conclusion.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2021 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Melian, María Elisa [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Dissolution efficiency |
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| Umfang: |
1 Online-Ressource (14 p) |
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| doi: |
10.4155/tde-2021-0014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL01109236X |
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| 245 | 1 | 0 | |a Dissolution profiles of fenbendazole from binary solid dispersions: a mathematical approach |c María Elisa Melian, Cintia Alejandra Briones Nieva, Laura Domínguez, Elio Emilio Gonzo, Santiago Palma, José María Bermúdez |
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| 520 | |a Aim:Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictablein vivoperformance.Materials & methods:Dissolution data of fenbendazole released from the SDs and the control physical mixtures were analyzed using the Lumped mathematical model to estimate the parameters of pharmaceutical relevance.Results:The fit data obtained by Lumped model showed that all SDs have a unique dissolution profile with an error of ±4.1% and an initial release rate 500-times higher than the pure drug, without incidence of drug/polymer ratio or polymer type.Conclusion:The Lumped model helped to understand that the main factor influencing the fenbendazole release was the type formulation (SD or physical mixture), regardless of the type or amount of polymer used. Aim: in vivo Materials & methods: Results: Conclusion | ||
| 653 | |a dissolution efficiency | ||
| 653 | |a drug release | ||
| 653 | |a fenbendazole | ||
| 653 | |a initial release rate | ||
| 653 | |a lumped model | ||
| 653 | |a mathematical model | ||
| 653 | |a poloxamer | ||
| 653 | |a solid dispersions | ||
| 700 | 1 | |a Briones Nieva, Cintia Alejandra |e verfasserin |4 aut | |
| 700 | 1 | |a Domínguez, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzo, Elio Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Palma, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Bermúdez, José María |e verfasserin |4 aut | |
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