Are there monogenic hereditary forms of bladder cancer or only genetic susceptibilities? / Tarek Souaid, Joya-Rita Hindy, Ernest Diab, Hampig Raphael Kourie
Bladder cancer (BC) is the most common cancer involving the urinary system and the ninth most common cancer worldwide. Tobacco smoking is the most important environmental risk factor of BC. Several single nucleotide polymorphisms have been validated by genome-wide association studies as genetic risk factors for BC. However, the identification of DNA mismatch-repair genes, includingMSH2in Lynch syndrome andMUTYHinMUTYH-associated polyposis, raises the possibility of monogenic hereditary forms of BC. Moreover, other genetic mutations may play a key role in familial and hereditary transmissions of BC. Therefore, the aim of this review is to focus on the major hereditary syndromes involved in the development of BC and to report BC genetic susceptibilities established with genome-wide significance level. MSH2 MUTYH MUTYH.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
Erscheinungsort nicht ermittelbar: 2021 |
| Enthalten in: |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Souaid, Tarek [VerfasserIn] |
|---|
| Links: |
FID Access [lizenzpflichtig] |
|---|
| Themen: |
|---|
| Umfang: |
1 Online-Ressource (10 p) |
|---|
| doi: |
10.2217/pgs-2020-0165 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
KFL011090782 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | KFL011090782 | ||
| 003 | DE-627 | ||
| 005 | 20231109205956.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230609s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2217/pgs-2020-0165 |2 doi | |
| 035 | |a (DE-627)KFL011090782 | ||
| 035 | |a (KFL)prod_FICIBQ_10.2217/pgs-2020-0165 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 084 | |a PHARM |q DE-84 |2 fid | ||
| 100 | 1 | |a Souaid, Tarek |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Are there monogenic hereditary forms of bladder cancer or only genetic susceptibilities? |c Tarek Souaid, Joya-Rita Hindy, Ernest Diab, Hampig Raphael Kourie |
| 264 | 1 | |a [Erscheinungsort nicht ermittelbar] |c 2021 | |
| 300 | |a 1 Online-Ressource (10 p) | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Bladder cancer (BC) is the most common cancer involving the urinary system and the ninth most common cancer worldwide. Tobacco smoking is the most important environmental risk factor of BC. Several single nucleotide polymorphisms have been validated by genome-wide association studies as genetic risk factors for BC. However, the identification of DNA mismatch-repair genes, includingMSH2in Lynch syndrome andMUTYHinMUTYH-associated polyposis, raises the possibility of monogenic hereditary forms of BC. Moreover, other genetic mutations may play a key role in familial and hereditary transmissions of BC. Therefore, the aim of this review is to focus on the major hereditary syndromes involved in the development of BC and to report BC genetic susceptibilities established with genome-wide significance level. MSH2 MUTYH MUTYH | ||
| 653 | |a bladder cancer | ||
| 653 | |a genetics | ||
| 653 | |a hereditary | ||
| 653 | |a Lynch | ||
| 653 | |a syndrome | ||
| 700 | 1 | |a Hindy, Joya-Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Diab, Ernest |e verfasserin |4 aut | |
| 700 | 1 | |a Kourie, Hampig Raphael |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmacogenomics |d London [u.a.] : Ashley, 2000 |h Online-Ressource |w (DE-627)KFL00000605X |w (DE-600)2030168-6 |w (DE-576)398099871 |x 1744-8042 |7 nnns |
| 856 | 4 | 0 | |u http://pharmazie.proxy.fid-lizenzen.de/fid/future-medicine-ejournals-pharmazie/doi.org/10.2217/pgs-2020-0165 |m X:KFL |x Resolving-System |y FID Access |z lizenzpflichtig |
| 912 | |a GBV_KFL | ||
| 912 | |a FID-PHARM | ||
| 935 | |i IMPORT_0628_prod_FICIBQ_03 | ||
| 951 | |a AR | ||