Prevention of abdominal adhesion by a polycaprolactone/phospholipid hybrid film containing quercetin and silver nanoparticles / Reza Hosseinpour-Moghadam, Shahram Rabbani, Arash Mahboubi, Sayyed Abbas Tabatabai, Azadeh Haeri
Aim:To develop quercetin-loaded poly(caprolactone) (PCL)/soybean phosphatidylcholine (PC) films coated with silver (Ag) to prevent the formation of postoperative adhesions (POA).Materials & methods:Films were prepared using the solvent casting method, coated with Ag, and underwent in vitrotests.In vivostudies were conducted employing an animal model of sidewall defect and cecum abrasion.Results:Films showed sustained release behavior of quercetin and Ag. Coating films with Ag improved their antimicrobial activity.In vivostudies confirmed superior antiadhesion properties of films compared with the control groups evaluated by gross observation, histochemical staining and immunohistochemistry analyses.Conclusion:Ag-Q-PCL-PC films are a potential candidate to prevent POA by acting as a sustained release delivery system and physical barrier. Aim: Materials & methods: in vitro In vivo Results: In vivo Conclusion: Graphical abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
Erscheinungsort nicht ermittelbar: 2021 |
| Enthalten in: |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hosseinpour-Moghadam, Reza [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Adhesion |
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| Umfang: |
1 Online-Ressource (16 p) |
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| doi: |
10.2217/nnm-2021-0209 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL011090103 |
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| 100 | 1 | |a Hosseinpour-Moghadam, Reza |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevention of abdominal adhesion by a polycaprolactone/phospholipid hybrid film containing quercetin and silver nanoparticles |c Reza Hosseinpour-Moghadam, Shahram Rabbani, Arash Mahboubi, Sayyed Abbas Tabatabai, Azadeh Haeri |
| 264 | 1 | |a [Erscheinungsort nicht ermittelbar] |c 2021 | |
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| 520 | |a Aim:To develop quercetin-loaded poly(caprolactone) (PCL)/soybean phosphatidylcholine (PC) films coated with silver (Ag) to prevent the formation of postoperative adhesions (POA).Materials & methods:Films were prepared using the solvent casting method, coated with Ag, and underwent in vitrotests.In vivostudies were conducted employing an animal model of sidewall defect and cecum abrasion.Results:Films showed sustained release behavior of quercetin and Ag. Coating films with Ag improved their antimicrobial activity.In vivostudies confirmed superior antiadhesion properties of films compared with the control groups evaluated by gross observation, histochemical staining and immunohistochemistry analyses.Conclusion:Ag-Q-PCL-PC films are a potential candidate to prevent POA by acting as a sustained release delivery system and physical barrier. Aim: Materials & methods: in vitro In vivo Results: In vivo Conclusion: Graphical abstract | ||
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