Nano-lipidic formulation and therapeutic strategies for Alzheimer’s disease via intranasal route / Shourya Tripathi, Ujala Gupta, Rewati Raman Ujjwal, Awesh K. Yadav
Abstract Aim The inability of drug molecules to cross the ‘Blood-Brain Barrier’ restrict the effective treatment of Alzheimer’s disease. Lipid nanocarriers have proven to be a novel paradigm in brain targeting of bioactive by facilitating suitable therapeutic concentrations to be attained in the brain. Methods The relevant information regarding the title of this review article was collected from the peer-reviewed published articles. Also, the physicochemical properties, and their in vitro and in vivo evaluations were presented in this review article. Results Administration of lipid-based nano-carriers have abilities to target the brain, improve the pharmacokinetic and pharmacodynamics properties of drugs, and mitigate the side effects of encapsulated therapeutic active agents. Conclusion Unlike oral and other routes, the Intranasal route promises high bioavailability, low first-pass effect, better pharmacokinetic properties, bypass of the systemic circulation, fewer incidences of unwanted side effects, and direct delivery of anti-AD drugs to the brain via circumventing ‘Blood-Brain Barrier’.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Sammelbände der Internationalen Musikgesellschaft - 38(2021), 7, Seite 572- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tripathi, Shourya [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (22 p) |
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| doi: |
10.1080/02652048.2021.1986585 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Aim The inability of drug molecules to cross the ‘Blood-Brain Barrier’ restrict the effective treatment of Alzheimer’s disease. Lipid nanocarriers have proven to be a novel paradigm in brain targeting of bioactive by facilitating suitable therapeutic concentrations to be attained in the brain. Methods The relevant information regarding the title of this review article was collected from the peer-reviewed published articles. Also, the physicochemical properties, and their in vitro and in vivo evaluations were presented in this review article. Results Administration of lipid-based nano-carriers have abilities to target the brain, improve the pharmacokinetic and pharmacodynamics properties of drugs, and mitigate the side effects of encapsulated therapeutic active agents. Conclusion Unlike oral and other routes, the Intranasal route promises high bioavailability, low first-pass effect, better pharmacokinetic properties, bypass of the systemic circulation, fewer incidences of unwanted side effects, and direct delivery of anti-AD drugs to the brain via circumventing ‘Blood-Brain Barrier’ | ||
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| 700 | 1 | |a Yadav, Awesh K. |e verfasserin |4 aut | |
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