Synthesis and Biological Screening of N,N'-bis Disubstituted Adipic Acid Thioureas / Aneela Maalik, Sadia Hameed, Huma Aslam Bhatti, Abdur Rauf, Syed Majid Bukhari, Nighat Fatima, Hummera Rafique, Ehsan Ullah Mughal, Amara Mumtaz
Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction. Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities. Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Current pharmaceutical analysis - 14(2018), 6, Seite 618- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maalik, Aneela [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (4 p) |
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| Förderinstitution / Projekttitel: |
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KFL009052321 |
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| 245 | 1 | 0 | |a Synthesis and Biological Screening of N,N'-bis Disubstituted Adipic Acid Thioureas |c Aneela Maalik, Sadia Hameed, Huma Aslam Bhatti, Abdur Rauf, Syed Majid Bukhari, Nighat Fatima, Hummera Rafique, Ehsan Ullah Mughal, Amara Mumtaz |
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| 520 | |a Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction. Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities. Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3 | ||
| 700 | 1 | |a Hameed, Sadia |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatti, Huma Aslam |e verfasserin |4 aut | |
| 700 | 1 | |a Rauf, Abdur |e verfasserin |4 aut | |
| 700 | 1 | |a Bukhari, Syed Majid |e verfasserin |4 aut | |
| 700 | 1 | |a Fatima, Nighat |e verfasserin |4 aut | |
| 700 | 1 | |a Rafique, Hummera |e verfasserin |4 aut | |
| 700 | 1 | |a Mughal, Ehsan Ullah |e verfasserin |4 aut | |
| 700 | 1 | |a Mumtaz, Amara |e verfasserin |4 aut | |
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