Emergence of Third Generation Cephalosporin Resistant Escherichia coli in Infants: Retrospective Study from a Tertiary Care Hospital in South India / Santhosh J. Thattil, Thekkuttuparambil A. Ajith
Aim: This study was aimed to evaluate the emergence of third generation cephalosporin resistant Escherichia coli isolated from the culture of various biological fluids of infants in a tertiary care hospital. Background: Resistance to commonly used antibiotics is consistently increasing during the last decades and it was found varying with time and geographical location. Objectives: To determine the prevalence of third generation cephalosporin sensitivity pattern of E. coli isolated from urine, stool, and throat swab culture from laboratory records. Methods: The retrospective study included the laboratory report of antibiotic sensitivity conducted on infants specimens during the period of 2 years. Third generation cephalosporin sensitivity patterns of E. coli isolated from urine, stool, and throat swab culture were collected and data were statistically analyzed. Results: Reports of 351 samples with positive E. coli were included in the study. More samples were analyzed from infants above 6 months of age with female dominance (184/351). Among the specimens tested, urine samples were highest 128/351 (35.0%). Cephalosporin resistant strain was found in 243/351 samples (69.2%) (p=0.0463) with 218/243 (89.7%) isolated from infants above 6 months of age and 25/243 (10.2%) were from infants below 6 months of age (p=0.038). The frequency of cephalosporin resistant E. coli in urine specimens of male and female infants was significant (p=0.0001). Conclusion: Third generation cephalosporin resistant E. coli strain was found in 69.2% of isolates and more in urine samples from female infants above 6 months of age. The clinicians should consider the emergence of cephalosporin resistant E. coli while selecting antibiotics as empirical treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Anti-infective agents - 19(2021), 2, Seite 215- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Thattil, Santhosh J. [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (5 p) |
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| Förderinstitution / Projekttitel: |
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KFL008961433 |
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| 245 | 1 | 0 | |a Emergence of Third Generation Cephalosporin Resistant Escherichia coli in Infants: Retrospective Study from a Tertiary Care Hospital in South India |c Santhosh J. Thattil, Thekkuttuparambil A. Ajith |
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| 520 | |a Aim: This study was aimed to evaluate the emergence of third generation cephalosporin resistant Escherichia coli isolated from the culture of various biological fluids of infants in a tertiary care hospital. Background: Resistance to commonly used antibiotics is consistently increasing during the last decades and it was found varying with time and geographical location. Objectives: To determine the prevalence of third generation cephalosporin sensitivity pattern of E. coli isolated from urine, stool, and throat swab culture from laboratory records. Methods: The retrospective study included the laboratory report of antibiotic sensitivity conducted on infants specimens during the period of 2 years. Third generation cephalosporin sensitivity patterns of E. coli isolated from urine, stool, and throat swab culture were collected and data were statistically analyzed. Results: Reports of 351 samples with positive E. coli were included in the study. More samples were analyzed from infants above 6 months of age with female dominance (184/351). Among the specimens tested, urine samples were highest 128/351 (35.0%). Cephalosporin resistant strain was found in 243/351 samples (69.2%) (p=0.0463) with 218/243 (89.7%) isolated from infants above 6 months of age and 25/243 (10.2%) were from infants below 6 months of age (p=0.038). The frequency of cephalosporin resistant E. coli in urine specimens of male and female infants was significant (p=0.0001). Conclusion: Third generation cephalosporin resistant E. coli strain was found in 69.2% of isolates and more in urine samples from female infants above 6 months of age. The clinicians should consider the emergence of cephalosporin resistant E. coli while selecting antibiotics as empirical treatment | ||
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