Molecular modeling and biological studies show that some -opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors
Aim:Despite the serious side effects, analgesics acting on opioid receptors are still considered the best way to get antinociception. Matrix metalloproteinases, a large family of zinc-dependent proteases implicated in many pathological conditions, such as diabetes and osteoarthritis, are also involved in inflammation and pain.Methodology & results:Looking for evidence of possible interactions of opioid pathways and inflammation mediators, molecular modeling studies of a series of recently developed -opioid receptor benzomorphanic agonists together with biological data on pain and inflammation molecular targets, allowed us to hypothesize a possible correlation between -opioid receptor system and MMP-9.Conclusion:A new compound, (-)-MML1017, emerged as a possible dual-acting agent able to interact selectively and potently with the two molecular targets. Aim: Methodology & results: Conclusion: Graphical abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Future medicinal chemistry - 11(2019), 11, Seite 1245- |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ronsisvalle, Simone [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (14 p) |
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| doi: |
10.4155/fmc-2018-0535 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Aim:Despite the serious side effects, analgesics acting on opioid receptors are still considered the best way to get antinociception. Matrix metalloproteinases, a large family of zinc-dependent proteases implicated in many pathological conditions, such as diabetes and osteoarthritis, are also involved in inflammation and pain.Methodology & results:Looking for evidence of possible interactions of opioid pathways and inflammation mediators, molecular modeling studies of a series of recently developed -opioid receptor benzomorphanic agonists together with biological data on pain and inflammation molecular targets, allowed us to hypothesize a possible correlation between -opioid receptor system and MMP-9.Conclusion:A new compound, (-)-MML1017, emerged as a possible dual-acting agent able to interact selectively and potently with the two molecular targets. Aim: Methodology & results: Conclusion: Graphical abstract | ||
| 700 | 1 | |a Spadaro, Angelo |e verfasserin |4 aut | |
| 700 | 1 | |a Tomasello, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Basile, Livia |e verfasserin |4 aut | |
| 700 | 1 | |a Panarello, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Franchini, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Renis, Marcella |e verfasserin |4 aut | |
| 700 | 1 | |a Guccione, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Crasc, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Panico, Anna Maria |e verfasserin |4 aut | |
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