A dispersive liquidliquid microextraction and chiral separation of carvedilol in human plasma using capillary electrophoresis / Samin Hamidi, Somaieh Soltani, Abolghasem Jouyban
Background:Development of simple, rapid and precise analysis of chiral drugs in biological samples is an important issue. Dispersive liquidliquid microextraction in combination with CE using field amplified sample injection has been of interest because of its capability to analyze trace amount of drugs.Methods:Dispersive liquidliquid microextraction-CE-field amplified sample injection was employed for chiral separation of carvedilol in human plasma using UV-DAD detector and the developed method has been validated according to US FDA method validation guideline for bioanalysis.Results:The method was linear over a concentration range of 12.5100 ng/ml for each carvedilol enantiomer (R20.998) and the mean recoveries ranged from 91 to 107.Conclusion:The method was adapted for sensitive, selective and rapid determination of carvedilol enantiomers in human plasma samples. Background: Methods: Results: 2 Conclusion.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Bioanalysis - 7(2015), 9, Seite 1107- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hamidi, Samin [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (11 p) |
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| doi: |
10.4155/bio.15.51 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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KFL001061925 |
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| 520 | |a Background:Development of simple, rapid and precise analysis of chiral drugs in biological samples is an important issue. Dispersive liquidliquid microextraction in combination with CE using field amplified sample injection has been of interest because of its capability to analyze trace amount of drugs.Methods:Dispersive liquidliquid microextraction-CE-field amplified sample injection was employed for chiral separation of carvedilol in human plasma using UV-DAD detector and the developed method has been validated according to US FDA method validation guideline for bioanalysis.Results:The method was linear over a concentration range of 12.5100 ng/ml for each carvedilol enantiomer (R20.998) and the mean recoveries ranged from 91 to 107.Conclusion:The method was adapted for sensitive, selective and rapid determination of carvedilol enantiomers in human plasma samples. Background: Methods: Results: 2 Conclusion | ||
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