Pharmacokinetic determination and analysis of nortriptyline based on GCMS coupled with hollow-fiber drop-to-drop solvent microextraction technique / Pratik Kumar Jagtap, Kavita Tapadia
Aim:A simple, sensitive and robust technique of hollow-fiber drop-to-drop solvent microextraction coupled with GCMS has been successfully developed for the detection of antidepressant drug nortriptyline in human blood and urine samples. The recoveries of the drug from the spiked samples are found to be well within the range and appropriate to support the method.Results:The LOD for the drug was obtained to be 0.007, 0.009 and 0.021g ml-1in deionized water, urine and blood samples of human subjects, respectively. Linearity was obtained over the concentration range of 0.55.0mg l-1in deionized water with correlation coefficient 0.99672. Aim: Results: -1 -1.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Bioanalysis - 10(2018), 3, Seite 143- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jagtap, Pratik Kumar [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (10 p) |
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| doi: |
10.4155/bio-2017-0207 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL001037617 |
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| 245 | 1 | 0 | |a Pharmacokinetic determination and analysis of nortriptyline based on GCMS coupled with hollow-fiber drop-to-drop solvent microextraction technique |c Pratik Kumar Jagtap, Kavita Tapadia |
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| 520 | |a Aim:A simple, sensitive and robust technique of hollow-fiber drop-to-drop solvent microextraction coupled with GCMS has been successfully developed for the detection of antidepressant drug nortriptyline in human blood and urine samples. The recoveries of the drug from the spiked samples are found to be well within the range and appropriate to support the method.Results:The LOD for the drug was obtained to be 0.007, 0.009 and 0.021g ml-1in deionized water, urine and blood samples of human subjects, respectively. Linearity was obtained over the concentration range of 0.55.0mg l-1in deionized water with correlation coefficient 0.99672. Aim: Results: -1 -1 | ||
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