Breast Milk Human Cytomegalovirus (CMV) Viral Load and the Establishment of Breast Milk CMV-pp65-Specific CD8 T Cells in Human CMV Infected Mothers
The role of human cytomegalovirus (HCMV)–specific T-cell responses in breast milk of HCMV-seropositive mothers is not well defined. In these studies, we demonstrate that the frequency of cytomegalovirus (CMV)-pp65–specific T-cell responses in peripheral blood mononuclear cells (PBMCs) and breast milk cells (BMCs) is increased for CD8+ T cells in both sample sources when compared with CD4+ T cells. The frequency of pp55-specific CD8 T cells producing interferon γ (IFN-γ) alone or dual IFN-γ/granzyme rB producers is increased in breast milk compared with PBMCs. Lastly, we observed a positive correlation between breast milk viral load and the CD8 pp65-specific response, suggesting that local virus replication drives antigen-specific CD8 T cells into the breast..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2017 |
---|---|
Erschienen: |
2017 |
Enthalten in: |
Zur Gesamtaufnahme - volume:216 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Moylan, David C. [VerfasserIn] |
---|
Links: |
---|
Themen: |
Breast milk |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
JST134615093 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | JST134615093 | ||
003 | DE-627 | ||
005 | 20240125161924.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230311s2017 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)JST134615093 | ||
035 | |a (JST)26491431 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Moylan, David C. |e verfasserin |4 aut | |
245 | 1 | 0 | |a Breast Milk Human Cytomegalovirus (CMV) Viral Load and the Establishment of Breast Milk CMV-pp65-Specific CD8 T Cells in Human CMV Infected Mothers |
264 | 1 | |c 2017 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a The role of human cytomegalovirus (HCMV)–specific T-cell responses in breast milk of HCMV-seropositive mothers is not well defined. In these studies, we demonstrate that the frequency of cytomegalovirus (CMV)-pp65–specific T-cell responses in peripheral blood mononuclear cells (PBMCs) and breast milk cells (BMCs) is increased for CD8+ T cells in both sample sources when compared with CD4+ T cells. The frequency of pp55-specific CD8 T cells producing interferon γ (IFN-γ) alone or dual IFN-γ/granzyme rB producers is increased in breast milk compared with PBMCs. Lastly, we observed a positive correlation between breast milk viral load and the CD8 pp65-specific response, suggesting that local virus replication drives antigen-specific CD8 T cells into the breast. | ||
540 | |a © The Author 2017 | ||
650 | 4 | |a breast milk | |
650 | 4 | |a CD8 T cells | |
650 | 4 | |a human cytomegalovirus (HCMV) | |
650 | 4 | |a cell-mediated immunity | |
650 | 4 | |a mucosal immunity | |
655 | 4 | |a research-article | |
700 | 1 | |a Pati, Sunil K. |e verfasserin |4 aut | |
700 | 1 | |a Ross, Shannon A. |e verfasserin |4 aut | |
700 | 1 | |a Fowler, Karen B. |e verfasserin |4 aut | |
700 | 1 | |a Boppana, Suresh B. |e verfasserin |4 aut | |
700 | 1 | |a Sabbaj, Steffanie |e verfasserin |4 aut | |
773 | 1 | 8 | |g volume:216 |g year:2017 |g number:9 |g pages:1176-1179 |
856 | 4 | 0 | |u https://www.jstor.org/stable/26491431 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_JST | ||
951 | |a AR | ||
952 | |d 216 |j 2017 |e 9 |h 1176-1179 |