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|a (JST)26364724
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|a DE-627
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|a eng
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|a Chen, Zhe
|e verfasserin
|4 aut
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|a Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
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|c 2017
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|a Text
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|a Computermedien
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|a Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.
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|a Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America
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|a research-article
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|a Bao, Linlin
|e verfasserin
|4 aut
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1 |
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|a Chen, Cong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zou, Tingting
|e verfasserin
|4 aut
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| 700 |
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|a Xue, Ying
|e verfasserin
|4 aut
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|a Li, Fengdi
|e verfasserin
|4 aut
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1 |
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|a Lv, Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Songzhi
|e verfasserin
|4 aut
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| 700 |
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|a Gao, Xiaopan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cui, Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jianmin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Chuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, Qi
|e verfasserin
|4 aut
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| 773 |
1 |
8 |
|g volume:215
|g year:2017
|g number:12
|g pages:1807-1815
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| 856 |
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|u https://www.jstor.org/stable/26364724
|3 Volltext
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|a AR
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|d 215
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|e 12
|h 1807-1815
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