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|a (JST)26166641
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|a DE-627
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|a eng
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|a Beaty, Shannon M.
|e verfasserin
|4 aut
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|a Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
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|a Online-Ressource
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|a To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuVJL5). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuVJL5-F/HNBMV) virus and rMuVJL5 were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuVJL5 infection had cross-neutralizing activity against rMuVJL5-F/HNBMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.
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|a Copyright © 2017 Oxford University Press on behalf of the Infectious Diseases Society of America
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|a research-article
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|a Nachbagauer, Raffael
|e verfasserin
|4 aut
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|a Hirsh, Ariana
|e verfasserin
|4 aut
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|a Vigant, Frederic
|e verfasserin
|4 aut
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|a Duehr, James
|e verfasserin
|4 aut
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|a Azarm, Kristopher D.
|e verfasserin
|4 aut
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|a Stelfox, Alice J.
|e verfasserin
|4 aut
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|a Bowden, Thomas A.
|e verfasserin
|4 aut
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|a Duprex, W. Paul
|e verfasserin
|4 aut
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|a Krammer, Florian
|e verfasserin
|4 aut
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|a Lee, Benhur
|e verfasserin
|4 aut
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| 773 |
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|g volume:215
|g year:2017
|g number:2
|g pages:209-213
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|u https://www.jstor.org/stable/26166641
|3 Volltext
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|a AR
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|d 215
|j 2017
|e 2
|h 209-213
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