B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis
The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell–mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
|---|---|
| Enthalten in: |
Clinical Infectious Diseases - 61(2015) vom: Okt., Seite S225-S234 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rao, Martin [VerfasserIn] |
|---|
| Links: |
|---|
| BKL: | |
|---|---|
| Themen: |
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
JST12834282X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | JST12834282X | ||
| 003 | DE-627 | ||
| 005 | 20230504234451.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210701s2015 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)JST12834282X | ||
| 035 | |a (JST)26369033 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q ASE |
| 084 | |a 44.75 |2 bkl | ||
| 100 | 1 | |a Rao, Martin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell–mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis. | ||
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Valentini, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Poiret, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Dodoo, Ernest |e verfasserin |4 aut | |
| 700 | 1 | |a Parida, Shreemanta |e verfasserin |4 aut | |
| 700 | 1 | |a Zumla, Alimuddin |e verfasserin |4 aut | |
| 700 | 1 | |a Brighenti, Susanna |e verfasserin |4 aut | |
| 700 | 1 | |a Maeurer, Markus |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i in |t Clinical Infectious Diseases |d Oxford University Press, 1992 |g 61(2015) vom: Okt., Seite S225-S234 |w (DE-627)JST025522906 |x 15376591 |7 nnns |
| 773 | 1 | 8 | |g volume:61 |g year:2015 |g month:10 |g pages:S225-S234 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/26369033 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_JST | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 44.75 |q ASE |
| 951 | |a AR | ||
| 952 | |d 61 |j 2015 |c 10 |h S225-S234 | ||