Metagenomic and Metabolomic Characterization of Rabies Encephalitis: New Insights into the Treatment of an Ancient Disease
Rabies virus (RV) infection is a fatal nervous system disorder. We describe a patient who died of rabies despite a neuroprotective intervention. Neuropathology showed neuronal loss with abundant RV antigen, genome, and Negri bodies, accompanied by intense neuroinflammation, including by CD8 + T lymphocyte infiltrates. Deep sequencing and real-time reverse-transcription polymerase chain reaction revealed RNA encoding a bat RV strain together with inflammatory gene induction. RV-infected brain demonstrated reduced neuronal metabolites with an anaerobic metabolic profile by nuclear magnetic resonance (NMR) spectroscopy. These multiplatform studies highlight the extent of ongoing viral replication coupled with inflammation in treated rabies, indicative of a neurological immune reconstitution inflammatory syndrome..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:207 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reinke, Stacey N. [VerfasserIn] |
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| Links: |
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| Themen: |
Biological sciences |
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| Förderinstitution / Projekttitel: |
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JST123868645 |
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| 100 | 1 | |a Reinke, Stacey N. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Metagenomic and Metabolomic Characterization of Rabies Encephalitis: New Insights into the Treatment of an Ancient Disease |
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| 520 | |a Rabies virus (RV) infection is a fatal nervous system disorder. We describe a patient who died of rabies despite a neuroprotective intervention. Neuropathology showed neuronal loss with abundant RV antigen, genome, and Negri bodies, accompanied by intense neuroinflammation, including by CD8 + T lymphocyte infiltrates. Deep sequencing and real-time reverse-transcription polymerase chain reaction revealed RNA encoding a bat RV strain together with inflammatory gene induction. RV-infected brain demonstrated reduced neuronal metabolites with an anaerobic metabolic profile by nuclear magnetic resonance (NMR) spectroscopy. These multiplatform studies highlight the extent of ongoing viral replication coupled with inflammation in treated rabies, indicative of a neurological immune reconstitution inflammatory syndrome. | ||
| 540 | |a Copyright © 2013 Oxford University Press on behalf of the Infectious Diseases Society of America | ||
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Infectious diseases |x Viral diseases |x RNA viral infections |x Rabies | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Brain | |
| 650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cells |x Neurons | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Brain |x Cerebrum |x White matter | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Brain |x Cerebrum |x Cerebral cortex | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Acids |x Nucleic acids |x RNA | |
| 650 | 4 | |a Physical sciences |x Earth sciences |x Geology |x Mineralogy |x Specimens | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Brain |x Cerebrum |x Basal ganglia | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms |x Viruses |x RNA viruses |x Rhabdoviridae |x Lyssavirus |x Rabies virus | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Nervous system diseases |x Central nervous system diseases |x Brain diseases |x Metabolic brain diseases |x MAJOR ARTICLES AND BRIEF REPORTS |x VIRUSES | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Resch, Lothar |e verfasserin |4 aut | |
| 700 | 1 | |a Maingat, Ferdinand |e verfasserin |4 aut | |
| 700 | 1 | |a Branton, William |e verfasserin |4 aut | |
| 700 | 1 | |a Jackson, Alan C. |e verfasserin |4 aut | |
| 700 | 1 | |a Holt, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Slupsky, Carolyn |e verfasserin |4 aut | |
| 700 | 1 | |a Marrie, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Sykes, Brian D. |e verfasserin |4 aut | |
| 700 | 1 | |a Power, Christopher |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:207 |g year:2013 |g number:9 |g pages:1451-1456 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/infdis/jis479 |3 Volltext |
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