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|a (JST)23770419
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|a DE-627
|b ger
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|a eng
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|a Hatcher, Rashieda J.
|e verfasserin
|4 aut
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|a Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
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|2 rdamedia
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|a Pituitary tumor transforming gene 1 (Pttg1) encodes the mammalian securin, which is an inhibitor of separase (a protease required for the separation of sister chromatids in mitosis and meiosis). PTTG1 is overexpressed in a number of human cancers and has been suggested to be an oncogene. However, we found that, in Pttg1-mutant females, the mammary epithelial cells showed increased proliferation and precocious branching morphogenesis. In accord with these phenotypic changes, progesterone receptor, cyclin D1, and Mmp2 were up-regulated whereas p21 (Cdkn1a) was down-regulated. These molecular changes provide explanation for the observed developmental defects, and suggest that Pttg1 is a tumor suppressor. Indeed, mice lacking Pttg1 developed spontaneous mammary tumors. Furthermore, in human breast tumors, PTTG1 protein levels were down-regulated and the reduction was significantly correlated with the tumor grade.
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|a copyright © 1993—2008 National Academy of Sciences of the United States of America
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|a Biological sciences
|x Biology
|x Anatomy
|x Body regions
|x Torso
|x Chest
|x Breasts
|x Mammary glands
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Neoplasia
|x Tumors
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Epithelial cells
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Developmental biology
|x Growth and development
|x Biological development
|x Morphogenesis
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Germ cells
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Molecular genetics
|x Genes
|x Dominant genes
|x Oncogenes
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mammals
|x Rodents
|x Mice
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animal anatomy
|x Animal morphology
|x Animal organs
|x Animal glands
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| 650 |
|
4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Breast diseases
|x Breast neoplasms
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Genetics
|x Molecular genetics
|x Gene expression
|x Gene expression regulation
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| 655 |
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|a research-article
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|a Dong, Jie
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Shuang
|e verfasserin
|4 aut
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| 700 |
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|a Bian, Guangxing
|e verfasserin
|4 aut
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| 700 |
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|a Contreras, Alejandro
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Tao
|e verfasserin
|4 aut
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| 700 |
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|a Hilsenbeck, Susan G.
|e verfasserin
|4 aut
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| 700 |
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|a Yi Li
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Pumin
|e verfasserin
|4 aut
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| 773 |
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|g volume:111
|g year:2014
|g number:3
|g pages:1008-1013
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|u https://www.jstor.org/stable/23770419
|3 Volltext
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|a GBV_JST
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|a AR
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|d 111
|j 2014
|e 3
|h 1008-1013
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