The Mathematical Biology of Human Infections
ABSTRACT Humans are constant victims of infectious diseases. Biomedical research during this century has led to important insights into the molecular details of immune defense. Yet, many questions relating to disease require a quantitative understanding of the complex systems that arise from the nonlinear interactions between populations of immune cells and infectious agents. Exploration of such questions has lead to a newly emerging field of mathematical biology describing the spread of infectious agents both within and between infected individuals. This essay will discuss simple and complex models of evolution, and the propagation of virus and prion infections. Such models provide new perspectives for our understanding of infectious disease and provide guidelines for interpreting experimental observation; they also define what needs to be measured to improve understanding..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1999 |
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| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nowak, Martin A. [VerfasserIn] |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST106064967 |
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| 520 | |a ABSTRACT Humans are constant victims of infectious diseases. Biomedical research during this century has led to important insights into the molecular details of immune defense. Yet, many questions relating to disease require a quantitative understanding of the complex systems that arise from the nonlinear interactions between populations of immune cells and infectious agents. Exploration of such questions has lead to a newly emerging field of mathematical biology describing the spread of infectious agents both within and between infected individuals. This essay will discuss simple and complex models of evolution, and the propagation of virus and prion infections. Such models provide new perspectives for our understanding of infectious disease and provide guidelines for interpreting experimental observation; they also define what needs to be measured to improve understanding. | ||
| 650 | 4 | |a CTL response | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a antivirals | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a immune response | |
| 650 | 4 | |a infectious diseases | |
| 650 | 4 | |a mathematical biology | |
| 650 | 4 | |a models of evolution | |
| 650 | 4 | |a prions | |
| 650 | 4 | |a resistance | |
| 650 | 4 | |a treatment | |
| 650 | 4 | |a viruses | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms |x Viruses | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Infections | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Leukocytes |x Mononuclear leukocytes |x Lymphocytes |x T lymphocytes | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms |x Viruses |x Oncogenic viruses |x Retroviridae |x Lentivirus |x Primate lentiviruses |x HIV | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Prions | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Pharmaceutics |x Pharmaceutical preparations |x Medications |x Antiinfectives |x Antivirals | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microbial physiology |x Viral morphology |x Virions | |
| 650 | 4 | |a Mathematics |x Mathematical analysis |x Mathematical models | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Adaptive immunity |x Active immunity |x Humoral immunity |x Antigens |x Epitopes | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Primates |x Humans |x perspective | |
| 655 | 4 | |a research-article | |
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