Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population
We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mamtani, Manju [VerfasserIn] |
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| Links: |
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| Themen: |
Biological sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST100954960 |
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| 245 | 1 | 0 | |a Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population |
| 264 | 1 | |c 2011 | |
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| 520 | |a We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. | ||
| 540 | |a Copyright © 2011 Oxford University Press on behalf of the Infectious Diseases Society of America | ||
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Genotypes |x Haplotypes | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Leukocytes |x Mononuclear leukocytes |x Lymphocytes |x T lymphocytes | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Infections |x Bacterial infections |x Gram positive bacterial infections |x Tuberculosis | |
| 650 | 4 | |a Biological sciences |x Biochemistry |x Biomolecules |x Chemokines | |
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Medical genetics | |
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Population genetics |x Genetic variation |x Genetic mutation |x Genetic polymorphism |x Gene dosage | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Immune system diseases |x AIDS | |
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Medical genetics |x Human genetics | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Receptors | |
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Genotypes |x MAJOR ARTICLES AND BRIEF REPORTS |x BACTERIA | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Mummidi, Srinivas |e verfasserin |4 aut | |
| 700 | 1 | |a Ramsuran, Veron |e verfasserin |4 aut | |
| 700 | 1 | |a Pham, Minh-Hieu |e verfasserin |4 aut | |
| 700 | 1 | |a Maldonado, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Begum, Kazi |e verfasserin |4 aut | |
| 700 | 1 | |a Valera, Maria Soledad |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez, Racquel |e verfasserin |4 aut | |
| 700 | 1 | |a Castiblanco, John |e verfasserin |4 aut | |
| 700 | 1 | |a Kulkarni, Hemant |e verfasserin |4 aut | |
| 700 | 1 | |a Ndung'u, Thumbi |e verfasserin |4 aut | |
| 700 | 1 | |a He, Weijing |e verfasserin |4 aut | |
| 700 | 1 | |a Anaya, Juan Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Ahuja, Sunil K. |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:203 |g year:2011 |g number:11 |g pages:1590-1594 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/infdis/jir145 |3 Volltext |
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| 952 | |d 203 |j 2011 |e 11 |h 1590-1594 | ||