Human immunoglobulin G levels of viruses and associated glioma risk
Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated prediagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2011 |
|---|---|
| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sjöström, Sara [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| doi: |
10.2307/41485207 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
JST091880106 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | JST091880106 | ||
| 003 | DE-627 | ||
| 005 | 20240115215638.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 151228s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2307/41485207 |2 doi | |
| 035 | |a (DE-627)JST091880106 | ||
| 035 | |a (JST)41485207 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sjöström, Sara |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Human immunoglobulin G levels of viruses and associated glioma risk |
| 264 | 1 | |c 2011 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated prediagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus. | ||
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Germ cell and embryonal neoplasms |x Glioma | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms |x Viruses | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Cancer | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Germ cell and embryonal neoplasms |x Glioma |x Astrocytoma |x Glioblastoma | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms |x Viruses |x DNA viruses |x Herpesviridae |x Cytomegalovirus | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Nervous system diseases |x Central nervous system diseases |x Brain diseases |x Brain neoplasms | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Tumors | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Adaptive immunity |x Active immunity |x Humoral immunity |x Antibodies | |
| 650 | 4 | |a Biological sciences |x Biology |x Microbiology |x Microorganisms |x Viruses |x Adenoviruses | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Hjalmars, Ulf |e verfasserin |4 aut | |
| 700 | 1 | |a Juto, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Wadell, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Hallmans, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Tjönneland, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Halkjaer, Jytte |e verfasserin |4 aut | |
| 700 | 1 | |a Manjer, Jonas |e verfasserin |4 aut | |
| 700 | 1 | |a Almquist, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Melin, Beatrice S. |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:22 |g year:2011 |g number:9 |g pages:1259-1266 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/41485207 |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.2307/41485207 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_JST | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2011 |e 9 |h 1259-1266 | ||