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151228s2010 xx |||||o 00| ||eng c |
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|a (DE-627)JST091762030
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|a (JST)40783096
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Carter, Rickey E.
|e verfasserin
|4 aut
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|a <bold>Relative risk estimated from the ratio of two median unbiased estimates</bold>
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
|b c
|2 rdamedia
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|a Online-Ressource
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|a Clinical trials often include binary end points. In some cases, no successes are observed and the usual large sample estimates of relative risk are undefined. The paper proposes an estimator for relative risk based on the median unbiased estimator. The relative risk estimator proposed is well defined and performs satisfactorily for a wide range of data configurations. To facilitate the use of the estimator, a deterministic bootstrap confidence interval is also proposed, and an SAS macro is available to perform the necessary calculations. An on-going randomized clinical trial motivated the development of the estimator and is used to illustrate the approach.
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|a © 2010 The Royal Statistical Society and Blackwell Publishing Ltd.
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| 650 |
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4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Statistical results
|x Statistical properties
|x Estimate reliability
|x Confidence interval
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| 650 |
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4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Descriptive statistics
|x Measures of variability
|x Sample size
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| 650 |
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4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Inferential statistics
|x Statistical estimation
|x Estimation methods
|x Estimators
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| 650 |
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4 |
|a Mathematics
|x Pure mathematics
|x Algebra
|x Polynomials
|x Binomials
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Medical research
|x Clinical research
|x Clinical trials
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| 650 |
|
4 |
|a Mathematics
|x Applied mathematics
|x Statistics
|x Applied statistics
|x Inferential statistics
|x Statistical estimation
|x Estimation methods
|x Estimators
|x Unbiased estimators
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| 650 |
|
4 |
|a Mathematics
|x Applied mathematics
|x Analytics
|x Analytical estimating
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| 650 |
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4 |
|a Philosophy
|x Applied philosophy
|x Philosophy of science
|x Scientific method
|x Hypothesis testing
|x Null hypothesis
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Metabolic diseases
|x Diabetes
|x Diabetes mellitus
|x Diabetes complications
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| 650 |
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4 |
|a Mathematics
|x Mathematical values
|x Ratios
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| 655 |
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4 |
|a research-article
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| 700 |
1 |
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|a Lin, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lipsitz, Stuart R.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Newcombe, Robert G.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hermayer, Kathie L.
|e verfasserin
|4 aut
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| 773 |
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8 |
|g volume:59
|g year:2010
|g number:4
|g pages:657-671
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| 856 |
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|u https://www.jstor.org/stable/40783096
|3 Volltext
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|d 59
|j 2010
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