Regulation of Proenkephalin by Fos and Jun
Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c-fos and c-jun expression was detected. Fos-Jun complexes bound specifically to a regulatory sequence in the 5$^{\prime}$ control region of the proenkephalin gene. Furthermore, c-fos and c-jun stimulated transcription from this control region synergistically in transactivation assays. These data suggest that the proenkephalin gene may be a physiological target for Fos and Jun in the hippocampus and indicate that these proto-oncogene transcription factors may play a role in neuronal responses to stimulation..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1989 |
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| Erschienen: |
1989 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:246 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sonnenberg, June L. [VerfasserIn] |
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| Links: |
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| Themen: |
Applied sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST078449839 |
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| 100 | 1 | |a Sonnenberg, June L. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Regulation of Proenkephalin by Fos and Jun |
| 264 | 1 | |c 1989 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c-fos and c-jun expression was detected. Fos-Jun complexes bound specifically to a regulatory sequence in the 5$^{\prime}$ control region of the proenkephalin gene. Furthermore, c-fos and c-jun stimulated transcription from this control region synergistically in transactivation assays. These data suggest that the proenkephalin gene may be a physiological target for Fos and Jun in the hippocampus and indicate that these proto-oncogene transcription factors may play a role in neuronal responses to stimulation. | ||
| 540 | |a Copyright 1989 The American Association for the Advancement of Science | ||
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| 655 | 4 | |a research-article | |
| 700 | 1 | |a Rauscher, Frank J. |e verfasserin |4 aut | |
| 700 | 1 | |a Morgan, James I. |e verfasserin |4 aut | |
| 700 | 1 | |a Curran, Tom |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:246 |g year:1989 |g number:4937 |g pages:1622-1625 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/1704679 |3 Volltext |
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