Selective 5-HT1DαSerotonin Receptor Gene Expression in Trigeminal Ganglia: Implications for Antimigraine Drug Development
Pharmacological data suggest that the actions of antimigraine drugs such as sumatriptan may be mediated by 5-HT1D-like serotonin receptors on trigeminovascular nerve endings. We sought molecular evidence for the expression of an mRNA species encoding the 5-HT1Dreceptor subtype in guinea pig and human trigeminal ganglia, using the polymerase chain reaction with oligonucleotides uniquely homologous to the coding sequences of the 5-HT1B/Dfamily (human 5-HT1D αand 5-HT1Dβ; rat 5-HT1B). A single band of predicted size was observed in samples from guinea pig trigeminal ganglia; sequence analysis revealed the presence of a single message, which was 85% and 71% identical to the human 5-HT1Dαand 5-HT1Dβreceptor DNA sequences, respectively. Similar analyses of postmortem human trigeminal ganglia revealed the presence of 5-HT1D α, but not 5-HT1Dβ, receptor message. Inasmuch as one recent report found that mRNA encoding only the 5-HT1Dβreceptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1Dαreceptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1994 |
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| Erschienen: |
1994 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:91 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rebeck, G. William [VerfasserIn] |
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| Links: |
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| Themen: |
Applied sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST070283222 |
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| 100 | 1 | |a Rebeck, G. William |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Selective 5-HT1DαSerotonin Receptor Gene Expression in Trigeminal Ganglia: Implications for Antimigraine Drug Development |
| 264 | 1 | |c 1994 | |
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| 520 | |a Pharmacological data suggest that the actions of antimigraine drugs such as sumatriptan may be mediated by 5-HT1D-like serotonin receptors on trigeminovascular nerve endings. We sought molecular evidence for the expression of an mRNA species encoding the 5-HT1Dreceptor subtype in guinea pig and human trigeminal ganglia, using the polymerase chain reaction with oligonucleotides uniquely homologous to the coding sequences of the 5-HT1B/Dfamily (human 5-HT1D αand 5-HT1Dβ; rat 5-HT1B). A single band of predicted size was observed in samples from guinea pig trigeminal ganglia; sequence analysis revealed the presence of a single message, which was 85% and 71% identical to the human 5-HT1Dαand 5-HT1Dβreceptor DNA sequences, respectively. Similar analyses of postmortem human trigeminal ganglia revealed the presence of 5-HT1D α, but not 5-HT1Dβ, receptor message. Inasmuch as one recent report found that mRNA encoding only the 5-HT1Dβreceptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1Dαreceptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache. | ||
| 540 | |a Copyright 1994 The National Academy of Sciences of the United States of America | ||
| 650 | 4 | |a Neurobiology | |
| 650 | 4 | |a Migraine | |
| 650 | 4 | |a Serotonin Receptor Subtypes | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Membrane proteins |x Cell surface receptors |x Serotonin receptors | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Receptors | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Ganglia |x Sensory ganglia |x Trigeminal ganglion | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Acids |x Nucleic acids |x DNA | |
| 650 | 4 | |a Applied sciences |x Laboratory techniques |x Nucleic acid amplification techniques |x Polymerase chain reaction | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Acids |x Nucleic acids |x DNA |x Single stranded DNA |x Complementary DNA | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Guinea pigs | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Acids |x Nucleic acids |x RNA | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Acids |x Nucleic acids |x RNA |x Messenger RNA | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Primates |x Humans | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Maynard, Kenneth I. |e verfasserin |4 aut | |
| 700 | 1 | |a Hyman, Bradley T. |e verfasserin |4 aut | |
| 700 | 1 | |a Moskowitz, Michael A. |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:91 |g year:1994 |g number:9 |g pages:3666-3669 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/2364511 |3 Volltext |
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| 952 | |d 91 |j 1994 |e 9 |h 3666-3669 | ||