The Intracellular Parasite Theileria parva Protects Infected T Cells from Apoptosis
Parasites have evolved a plethora of strategies to ensure their survival. The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting and transforming T cells, inducing their continuous proliferation and rendering them metastatic. In previous work, we have shown that the parasite induces constitutive activation of the transcription factor NF-κ B, by inducing the constitutive degradation of its cytoplasmic inhibitors. The biological significance of NF-κ B activation in T. parva-infected cells, however, has not yet been defined. Cells that have been transformed by viruses or oncogenes can persist only if they manage to avoid destruction by the apoptotic mechanisms that are activated on transformation and that contribute to maintain cellular homeostasis. We now demonstrate that parasite-induced NF-κ B activation plays a crucial role in the survival of T. parva-transformed T cells by conveying protection against an apoptotic signal that accompanies parasite-mediated transformation. Consequently, inhibition of NF-κ B nuclear translocation and the expression of dominant negative mutant forms of components of the NF-κ B activation pathway, such as Iκ Bα or p65, prompt rapid apoptosis of T. parva-transformed T cells. Our findings offer important insights into parasite survival strategies and demonstrate that parasite-induced constitutive NF-κ B activation is an essential step in maintaining the transformed phenotype of the infected cells..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
1999 |
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Erschienen: |
1999 |
Enthalten in: |
Zur Gesamtaufnahme - volume:96 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
Heussler, Volker T. [VerfasserIn] |
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Themen: |
Biological sciences |
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PPN (Katalog-ID): |
JST070245185 |
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100 | 1 | |a Heussler, Volker T. |e verfasserin |4 aut | |
245 | 1 | 4 | |a The Intracellular Parasite Theileria parva Protects Infected T Cells from Apoptosis |
264 | 1 | |c 1999 | |
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520 | |a Parasites have evolved a plethora of strategies to ensure their survival. The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting and transforming T cells, inducing their continuous proliferation and rendering them metastatic. In previous work, we have shown that the parasite induces constitutive activation of the transcription factor NF-κ B, by inducing the constitutive degradation of its cytoplasmic inhibitors. The biological significance of NF-κ B activation in T. parva-infected cells, however, has not yet been defined. Cells that have been transformed by viruses or oncogenes can persist only if they manage to avoid destruction by the apoptotic mechanisms that are activated on transformation and that contribute to maintain cellular homeostasis. We now demonstrate that parasite-induced NF-κ B activation plays a crucial role in the survival of T. parva-transformed T cells by conveying protection against an apoptotic signal that accompanies parasite-mediated transformation. Consequently, inhibition of NF-κ B nuclear translocation and the expression of dominant negative mutant forms of components of the NF-κ B activation pathway, such as Iκ Bα or p65, prompt rapid apoptosis of T. parva-transformed T cells. Our findings offer important insights into parasite survival strategies and demonstrate that parasite-induced constitutive NF-κ B activation is an essential step in maintaining the transformed phenotype of the infected cells. | ||
540 | |a Copyright 1993-1999 The National Academy of Sciences of the United States of America | ||
650 | 4 | |a Cell Biology | |
650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Leukocytes |x Mononuclear leukocytes |x Lymphocytes |x T lymphocytes | |
650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cell physiology |x Cell death |x Apoptosis | |
650 | 4 | |a Biological sciences |x Ecology |x Ecological processes |x Ecosystem dynamics |x Trophic dynamics |x Trophic levels |x Heterotrophs |x Parasites | |
650 | 4 | |a Biological sciences |x Biology |x Genetics |x Genetic research |x Genetic engineering |x Gene transfer techniques |x Transfection | |
650 | 4 | |a Biological sciences |x Biology |x Parasitology |x Parasitism | |
650 | 4 | |a Physical sciences |x Chemistry |x Chemical reactions |x Functional group transfer |x Phosphorylation | |
650 | 4 | |a Biological sciences |x Biology |x Genetics |x Genetic research |x Genetic vectors |x Plasmids | |
650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cellular structures |x Cell membranes | |
650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cell physiology |x Cell growth | |
650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cells |x Cultured cells |x Cell lines |x 3T3 cells | |
655 | 4 | |a research-article | |
700 | 1 | |a Machado,, Joel |e verfasserin |4 aut | |
700 | 1 | |a Fernandez, Paula C. |e verfasserin |4 aut | |
700 | 1 | |a Botteron, Catherine |e verfasserin |4 aut | |
700 | 1 | |a Chen, Chao-Guang |e verfasserin |4 aut | |
700 | 1 | |a Pearse, Martin J. |e verfasserin |4 aut | |
773 | 1 | 8 | |g volume:96 |g year:1999 |g number:13 |g pages:7312-7317 |
856 | 4 | 0 | |u https://www.jstor.org/stable/48055 |3 Volltext |
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