Microtubule-Binding Drugs Offset Tau Sequestration by Stabilizing Microtubules and Reversing Fast Axonal Transport Deficits in a Tauopathy Model
We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally substituting for the MT-binding protein tau, which is sequestered into inclusions of human tauopathies and transgenic mouse models thereof. Transgenic mice were treated for 12 weeks with weekly i.p. injections of 10 or 25 mg/ m2paclitaxel (Paxceed). Both doses restored fast axonal transport in spinal axons, wherein MT numbers and stable (detyrosinated) tubulins were increased, compared with sham treatment, and only Paxceed ameliorated motor impairments in tau transgenic mice. Thus, MT-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this MT-stabilizing protein into filamentous inclusions..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2005 |
|---|---|
| Erschienen: |
2005 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zhang, Bin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Applied sciences |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
JST069962227 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | JST069962227 | ||
| 003 | DE-627 | ||
| 005 | 20240117000714.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 150325s2005 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)JST069962227 | ||
| 035 | |a (JST)3374155 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zhang, Bin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Microtubule-Binding Drugs Offset Tau Sequestration by Stabilizing Microtubules and Reversing Fast Axonal Transport Deficits in a Tauopathy Model |
| 264 | 1 | |c 2005 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a We tested the hypothesis that microtubule (MT)-binding drugs could be therapeutically beneficial in tauopathies by functionally substituting for the MT-binding protein tau, which is sequestered into inclusions of human tauopathies and transgenic mouse models thereof. Transgenic mice were treated for 12 weeks with weekly i.p. injections of 10 or 25 mg/ m2paclitaxel (Paxceed). Both doses restored fast axonal transport in spinal axons, wherein MT numbers and stable (detyrosinated) tubulins were increased, compared with sham treatment, and only Paxceed ameliorated motor impairments in tau transgenic mice. Thus, MT-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this MT-stabilizing protein into filamentous inclusions. | ||
| 540 | |a Copyright 1993/2005 The National Academy of Sciences of the United States of America | ||
| 650 | 4 | |a Paxceed | |
| 650 | 4 | |a Transgenic mice | |
| 650 | 4 | |a Ventral root | |
| 650 | 4 | |a Neurodegeneration | |
| 650 | 4 | |a Therapy | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Peripheral nervous system |x Peripheral nerves |x Spinal nerves |x Spinal Nerve roots | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Nervous system diseases |x Neurodegenerative diseases |x Tauopathies | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Nerves |x Nerve fibers |x Axons | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Spinal cord | |
| 650 | 4 | |a Mathematics |x Pure mathematics |x Geometry |x Geometric shapes |x Spheroids | |
| 650 | 4 | |a Applied sciences |x Applied chemistry |x Pharmaceutical chemistry |x Drug design | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Transgenic animals | |
| 650 | 4 | |a Health sciences |x Medical treatment | |
| 650 | 4 | |a Biological sciences |x Biology |x Anatomy |x Nervous system |x Central nervous system |x Biological Sciences | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Maiti, Arpita |e verfasserin |4 aut | |
| 700 | 1 | |a Shively, Sharon |e verfasserin |4 aut | |
| 700 | 1 | |a Lakhani, Fara |e verfasserin |4 aut | |
| 700 | 1 | |a McDonald-Jones, Gaye |e verfasserin |4 aut | |
| 700 | 1 | |a Bruce, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Edward B. |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Sharon X. |e verfasserin |4 aut | |
| 700 | 1 | |a Joyce, Sonali |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Toleikis, Philip M. |e verfasserin |4 aut | |
| 700 | 1 | |a Trojanowski, John Q. |e verfasserin |4 aut | |
| 700 | 1 | |a Iversen, L. L. |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:102 |g year:2005 |g number:1 |g pages:227-231 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/3374155 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_JST | ||
| 951 | |a AR | ||
| 952 | |d 102 |j 2005 |e 1 |h 227-231 | ||