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150325s2004 xx |||||o 00| ||eng c |
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|a (DE-627)JST069898162
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|a (JST)3373983
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|a DE-627
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|a eng
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|a Graveel, Carrie
|e verfasserin
|4 aut
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|a Activating Met Mutations Produce Unique Tumor Profiles in Mice with Selective Duplication of the Mutant Allele
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|c 2004
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|a Text
|b txt
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|a Computermedien
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|a Online-Ressource
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|a Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers. These mutations have been examined in several in vitro systems, where they cause constitutive Met activation, focus formation, and cell motility, and are tumorigenic in xenografts. To study the influence of these mutations on tumorigenesis in vivo, we generated mice with targeted mutations in the murine met locus. The following five mouse lines with mutant Met were created: WT, D1226N, Y1228C, M1248T, and M1248T/L1193V. We observed that mice harboring D1226N, Y1228C, and M1248T/L1193V mutations developed a high frequency of sarcomas and some lymphomas, whereas the M1248T mice developed carcinomas and lymphomas. Of considerable interest, we observed trisomy of chromosome 6 and duplication of the mutant met allele in a majority of the tumors, similar to what has been reported in patients with hereditary renal papillary carcinomas. These results demonstrate that activating Met mutations and met amplification play key roles in promoting tumorigenesis in vivo. Moreover, our findings show that different mutations in the Met kinase domain can influence the types of cancers that develop.
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|a Copyright 1993/2004 The National Academy of Sciences of the United States of America
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Neoplasia
|x Tumors
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Population genetics
|x Genetic variation
|x Genetic mutation
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Molecular genetics
|x Genes
|x Alleles
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Neoplasia
|x Sarcoma
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cellular structures
|x Intracellular space
|x Organelles
|x Cell nucleus
|x Chromosomes
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Hematologic diseases
|x Hematologic neoplasms
|x Hemangiosarcoma
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mammals
|x Rodents
|x Mice
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Genomics
|x Genomes
|x Genetic loci
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Genetics
|x Cytogenetics
|x Chromosome morphology
|x Chromosome aberrations
|x Aneuploidy
|x Trisomy
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Neoplasia
|x Cancer
|x Biological Sciences
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| 655 |
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4 |
|a research-article
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| 700 |
1 |
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|a Su, Yanli
|e verfasserin
|4 aut
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|a Koeman, Julie
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Ling-Mei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tessarollo, Lino
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fiscella, Michele
|e verfasserin
|4 aut
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| 700 |
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|a Birchmeier, Carmen
|e verfasserin
|4 aut
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| 700 |
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|a Swiatek, Pamela
|e verfasserin
|4 aut
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|a Bronson, Roderick
|e verfasserin
|4 aut
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| 700 |
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|a Woude, George Vande
|e verfasserin
|4 aut
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| 773 |
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|g volume:101
|g year:2004
|g number:49
|g pages:17198-17203
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|u https://www.jstor.org/stable/3373983
|3 Volltext
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|d 101
|j 2004
|e 49
|h 17198-17203
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