Innate Response to Self-Antigen Significantly Exacerbates Burn Wound Depth
A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suber, Freeman [VerfasserIn] |
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| Links: |
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| Themen: |
Applied sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST069883106 |
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| 100 | 1 | |a Suber, Freeman |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Innate Response to Self-Antigen Significantly Exacerbates Burn Wound Depth |
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| 520 | |a A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response. | ||
| 540 | |a Copyright 2007 The National Academy of Sciences of the United States of America | ||
| 650 | 4 | |a Complement | |
| 650 | 4 | |a Natural IgM | |
| 650 | 4 | |a Trauma | |
| 650 | 4 | |a Wound physiology | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Physical trauma | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Physical trauma |x Burns | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Inflammation | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Physical trauma |x Wounds | |
| 650 | 4 | |a Social sciences |x Food studies |x Culinary arts |x Food preparation |x Cooking |x Scalding | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x System physiology |x Cardiovascular physiology |x Blood circulation |x Hemodynamics |x Blood flow | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Musculoskeletal diseases |x Joint diseases |x Contracture | |
| 650 | 4 | |a Applied sciences |x Engineering |x Optical engineering |x Optical equipment |x Lasers | |
| 650 | 4 | |a Biological sciences |x Biology |x Cytology |x Histology | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Physical trauma | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Physical trauma |x Burns | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Inflammation | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Physical trauma |x Wounds | |
| 650 | 4 | |a Social sciences |x Food studies |x Culinary arts |x Food preparation |x Cooking |x Scalding | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x System physiology |x Cardiovascular physiology |x Blood circulation |x Hemodynamics |x Blood flow | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Musculoskeletal diseases |x Joint diseases |x Contracture | |
| 650 | 4 | |a Applied sciences |x Engineering |x Optical engineering |x Optical equipment |x Lasers | |
| 650 | 4 | |a Biological sciences |x Biology |x Cytology |x Histology | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Carroll, Michael C. |e verfasserin |4 aut | |
| 700 | 1 | |a Moore,, Francis D. |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:104 |g year:2007 |g number:10 |g pages:3973-3977 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/25426766 |3 Volltext |
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