Severe B Cell Hyperplasia and Autoimmune Disease in TALL-1 Transgenic Mice
TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a β -actin promoter. The TALL-1 transgenic mice showed severe enlargement of spleen, lymph nodes, and Peyer's patches because of an increased number of B220+ cells. The transgenic mice also had hypergammaglobulinemia contributed by elevations of serum IgM, IgG, IgA, and IgE. In addition, a phenotype similar to autoimmune lupus-like disease was also seen in TALL-1 transgenic mice, characterized by the presence of autoantibodies to nuclear antigens and immune complex deposits in the kidney. Prolonged survival and hyperactivity of transgenic B cells may contribute to the autoimmune lupus-like phenotype in these animals. Our studies further confirm TALL-1 as a stimulator of B cells that affect Ig production. Thus, TALL-1 may be a primary mediator in B cell-associated autoimmune diseases..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2000 |
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| Erschienen: |
2000 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Khare, Sanjay D. [VerfasserIn] |
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| Links: |
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| Themen: |
Biological sciences |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
JST069726116 |
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| 100 | 1 | |a Khare, Sanjay D. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Severe B Cell Hyperplasia and Autoimmune Disease in TALL-1 Transgenic Mice |
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| 520 | |a TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a β -actin promoter. The TALL-1 transgenic mice showed severe enlargement of spleen, lymph nodes, and Peyer's patches because of an increased number of B220+ cells. The transgenic mice also had hypergammaglobulinemia contributed by elevations of serum IgM, IgG, IgA, and IgE. In addition, a phenotype similar to autoimmune lupus-like disease was also seen in TALL-1 transgenic mice, characterized by the presence of autoantibodies to nuclear antigens and immune complex deposits in the kidney. Prolonged survival and hyperactivity of transgenic B cells may contribute to the autoimmune lupus-like phenotype in these animals. Our studies further confirm TALL-1 as a stimulator of B cells that affect Ig production. Thus, TALL-1 may be a primary mediator in B cell-associated autoimmune diseases. | ||
| 540 | |a Copyright 1993-2000 National Academy of Sciences of the United States of America | ||
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Leukocytes |x Mononuclear leukocytes |x Lymphocytes |x B lymphocytes | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Transgenic animals | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Immune system diseases |x Autoimmune diseases |x Lupus | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Adaptive immunity |x Active immunity |x Humoral immunity |x Antibodies | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Leukocytes |x Mononuclear leukocytes |x Lymphocytes |x T lymphocytes | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Immune system diseases |x Autoimmune diseases | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Adaptive immunity |x Active immunity |x Humoral immunity |x Antibodies |x Autoantibodies | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Receptors | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Benign neoplasms |x Hyperplasia |x Biological Sciences | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Sarosi, Ildiko |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Xing-Zhong |e verfasserin |4 aut | |
| 700 | 1 | |a McCabe, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Miner, Kent |e verfasserin |4 aut | |
| 700 | 1 | |a Solovyev, Irina |e verfasserin |4 aut | |
| 700 | 1 | |a Hawkins, Nessa |e verfasserin |4 aut | |
| 700 | 1 | |a Kelley, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, David |e verfasserin |4 aut | |
| 700 | 1 | |a Van, Gwyneth |e verfasserin |4 aut | |
| 700 | 1 | |a Ross, Larry |e verfasserin |4 aut | |
| 700 | 1 | |a Delaney, John |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Lacey, David |e verfasserin |4 aut | |
| 700 | 1 | |a Boyle, William J. |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Hailing |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:97 |g year:2000 |g number:7 |g pages:3370-3375 |
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