Human Serotonin 1D Receptor is Encoded by a Subfamily of Two Distinct Genes: 5-HT1Dαand 5-HT1Dβ
The serotonin 1D (5-HT1D) receptor is a pharmacologically defined binding site and functional receptor site. Observed variations in the properties of 5-HT1Dreceptors in different tissues have led to the speculation that multiple receptor proteins with slightly different properties may exist. We report here the cloning, deduced amino acid sequences, pharmacological properties, and second-messenger coupling of a pair of human 5-HT1Dreceptor genes, which we have designated 5-HT1Dαand 5-HT1Dβdue to their strong similarities in sequence, pharmacological properties, and second-messenger coupling. Both genes are free of introns in their coding regions, are expressed in the human cerebral cortex, and can couple to inhibition of adenylate cyclase activity. The pharmacological binding properties of these two human receptors are very similar, and match closely the pharmacological properties of human, bovine, and guinea pig 5-HT1Dsites. Both receptors exhibit high-affinity binding of sumatriptan, a new anti-migraine medication, and thus are candidates for the pharmacological site of action of this drug..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1992 |
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| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Weinshank, Richard L. [VerfasserIn] |
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| Links: |
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| Themen: |
Biological sciences |
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| PPN (Katalog-ID): |
JST069641498 |
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| 100 | 1 | |a Weinshank, Richard L. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Human Serotonin 1D Receptor is Encoded by a Subfamily of Two Distinct Genes: 5-HT1Dαand 5-HT1Dβ |
| 264 | 1 | |c 1992 | |
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| 520 | |a The serotonin 1D (5-HT1D) receptor is a pharmacologically defined binding site and functional receptor site. Observed variations in the properties of 5-HT1Dreceptors in different tissues have led to the speculation that multiple receptor proteins with slightly different properties may exist. We report here the cloning, deduced amino acid sequences, pharmacological properties, and second-messenger coupling of a pair of human 5-HT1Dreceptor genes, which we have designated 5-HT1Dαand 5-HT1Dβdue to their strong similarities in sequence, pharmacological properties, and second-messenger coupling. Both genes are free of introns in their coding regions, are expressed in the human cerebral cortex, and can couple to inhibition of adenylate cyclase activity. The pharmacological binding properties of these two human receptors are very similar, and match closely the pharmacological properties of human, bovine, and guinea pig 5-HT1Dsites. Both receptors exhibit high-affinity binding of sumatriptan, a new anti-migraine medication, and thus are candidates for the pharmacological site of action of this drug. | ||
| 540 | |a Copyright 1992 The National Academy of Sciences of the United States of America | ||
| 650 | 4 | |a Pharmacology | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Membrane proteins |x Cell surface receptors |x Serotonin receptors | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Receptors | |
| 650 | 4 | |a Health sciences |x Medical sciences |x Pharmacology | |
| 650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cells |x Cultured cells |x Cell lines | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Acids |x Amino acids | |
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Genetic research |x Genetic engineering |x Gene transfer techniques |x Transfection | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Agonists | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Ligands | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Canines | |
| 650 | 4 | |a Biological sciences |x Biology |x Genetics |x Genomics | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Zgombick, John M. |e verfasserin |4 aut | |
| 700 | 1 | |a Macchi, Mary J. |e verfasserin |4 aut | |
| 700 | 1 | |a Branchek, Theresa A. |e verfasserin |4 aut | |
| 700 | 1 | |a Hartig, Paul R. |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:89 |g year:1992 |g number:8 |g pages:3630-3634 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/2359154 |3 Volltext |
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| 952 | |d 89 |j 1992 |e 8 |h 3630-3634 | ||