Reversal of Tolerance to Human MUC1 Antigen in MUC1 Transgenic Mice Immunized with Fusions of Dendritic and Carcinoma Cells
Immunological unresponsiveness established by the elimination or anergy of self-reactive lymphocyte clones is of importance to immunization against tumor-associated antigens. In this study, we have investigated induction of immunity against the human MUC1 carcinoma-associated antigen in MUC1 transgenic mice unresponsive to MUC1 antigen. Immunization of adult MUC1 transgenic mice with irradiated MUC1-positive tumor cells was unsuccessful in reversing unresponsiveness to MUC1. By contrast, fusions of dendritic cells with MUC1-positive tumor cells induced cellular and humoral immunity against MUC1. Immunization with the dendritic cell fusions that express MUC1 resulted in the rejection of established metastases and no apparent autoimmunity against normal tissues. These findings demonstrate that unresponsiveness to the MUC1 tumor-associated antigen is reversible by immunization with heterokaryons of dendritic cells and MUC1-positive carcinoma cells..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
1998 |
---|---|
Erschienen: |
1998 |
Enthalten in: |
Zur Gesamtaufnahme - volume:95 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Gong, Jianlin [VerfasserIn] |
---|
Links: |
---|
Themen: |
Biological sciences |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
JST069512272 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | JST069512272 | ||
003 | DE-627 | ||
005 | 20240117002953.0 | ||
007 | cr uuu---uuuuu | ||
008 | 150325s1998 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)JST069512272 | ||
035 | |a (JST)45370 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Gong, Jianlin |e verfasserin |4 aut | |
245 | 1 | 0 | |a Reversal of Tolerance to Human MUC1 Antigen in MUC1 Transgenic Mice Immunized with Fusions of Dendritic and Carcinoma Cells |
264 | 1 | |c 1998 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Immunological unresponsiveness established by the elimination or anergy of self-reactive lymphocyte clones is of importance to immunization against tumor-associated antigens. In this study, we have investigated induction of immunity against the human MUC1 carcinoma-associated antigen in MUC1 transgenic mice unresponsive to MUC1 antigen. Immunization of adult MUC1 transgenic mice with irradiated MUC1-positive tumor cells was unsuccessful in reversing unresponsiveness to MUC1. By contrast, fusions of dendritic cells with MUC1-positive tumor cells induced cellular and humoral immunity against MUC1. Immunization with the dendritic cell fusions that express MUC1 resulted in the rejection of established metastases and no apparent autoimmunity against normal tissues. These findings demonstrate that unresponsiveness to the MUC1 tumor-associated antigen is reversible by immunization with heterokaryons of dendritic cells and MUC1-positive carcinoma cells. | ||
540 | |a Copyright 1993-1998 National Academy of Sciences | ||
650 | 4 | |a Immunology | |
650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Leukocytes |x Mononuclear leukocytes |x Lymphocytes |x T lymphocytes | |
650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immune system |x Immune response |x Adaptive immunity |x Active immunity |x Humoral immunity |x Antigens | |
650 | 4 | |a Health sciences |x Medical treatment |x Biological therapy |x Immunotherapy |x Immunization | |
650 | 4 | |a Biological sciences |x Biology |x Cytology |x Cell biology |x Cells |x Antigen presenting cells | |
650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Cancer |x Carcinoma | |
650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Tumors | |
650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Transgenic animals | |
650 | 4 | |a Health sciences |x Medical treatment |x Biological therapy |x Immunotherapy |x Immunization |x Vaccination | |
650 | 4 | |a Health sciences |x Medical sciences |x Immunology |x Immunity | |
655 | 4 | |a research-article | |
700 | 1 | |a Chen, Dongshu |e verfasserin |4 aut | |
700 | 1 | |a Kashiwaba, Masahiro |e verfasserin |4 aut | |
700 | 1 | |a Li, Yongqing |e verfasserin |4 aut | |
700 | 1 | |a Chen, Ling |e verfasserin |4 aut | |
700 | 1 | |a Takeuchi, Hideya |e verfasserin |4 aut | |
700 | 1 | |a Qu, Hui |e verfasserin |4 aut | |
700 | 1 | |a Rowse, Gerald J. |e verfasserin |4 aut | |
700 | 1 | |a Gendler, Sandra J. |e verfasserin |4 aut | |
700 | 1 | |a Kufe, Donald |e verfasserin |4 aut | |
773 | 1 | 8 | |g volume:95 |g year:1998 |g number:11 |g pages:6279-6283 |
856 | 4 | 0 | |u https://www.jstor.org/stable/45370 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_JST | ||
951 | |a AR | ||
952 | |d 95 |j 1998 |e 11 |h 6279-6283 |