Platelet Glycoprotein Ibα Supports Experimental Lung Metastasis
The platelet paradigm in hemostasis and thrombosis involves an initiation step that depends on platelet membrane receptors binding to ligands on a damaged or inflamed vascular surface. Once bound to the surface, platelets provide a unique microenvironment supporting the accumulation of more platelets and the elaboration of a fibrin-rich network produced by coagulation factors. The platelet-specific receptor glycoprotein (GP) Ib-IX, is critical in this process and initiates the formation of a platelet-rich thrombus by tethering the platelet to a thrombogenic surface. A role for platelets beyond the hemostasis/thrombosis paradigm is emerging with significant platelet contributions in both tumorigenesis and inflammation. We have established congenie (N10) mouse colonies (C57BL/6J) with dysfunctional GP Ib-IX receptors in our laboratory that allow us an opportunity to examine the relevance of platelet GP Ib-IX in syngeneic mouse models of experimental metastasis. Our results demonstrate platelet GP Ib-IX contributes to experimental metastasis because a functional absence of GP Ib-IX correlates with a 15-fold reduction in the number of lung metastatic foci using B16F10.1 melanoma cells. The results demonstrate that the extracellular domain of the α-subunit of GP Ib is the structurally relevant component of the GP Ib-IX complex contributing to metastasis. Our results support the hypothesis that platelet GP Ib-IX functions that support normal hemostasis or pathologic thrombosis also contribute to tumor malignancy..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jain, Shashank [VerfasserIn] |
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| Links: |
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| Themen: |
Adhesion |
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| PPN (Katalog-ID): |
JST06945339X |
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| 245 | 1 | 0 | |a Platelet Glycoprotein Ibα Supports Experimental Lung Metastasis |
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| 520 | |a The platelet paradigm in hemostasis and thrombosis involves an initiation step that depends on platelet membrane receptors binding to ligands on a damaged or inflamed vascular surface. Once bound to the surface, platelets provide a unique microenvironment supporting the accumulation of more platelets and the elaboration of a fibrin-rich network produced by coagulation factors. The platelet-specific receptor glycoprotein (GP) Ib-IX, is critical in this process and initiates the formation of a platelet-rich thrombus by tethering the platelet to a thrombogenic surface. A role for platelets beyond the hemostasis/thrombosis paradigm is emerging with significant platelet contributions in both tumorigenesis and inflammation. We have established congenie (N10) mouse colonies (C57BL/6J) with dysfunctional GP Ib-IX receptors in our laboratory that allow us an opportunity to examine the relevance of platelet GP Ib-IX in syngeneic mouse models of experimental metastasis. Our results demonstrate platelet GP Ib-IX contributes to experimental metastasis because a functional absence of GP Ib-IX correlates with a 15-fold reduction in the number of lung metastatic foci using B16F10.1 melanoma cells. The results demonstrate that the extracellular domain of the α-subunit of GP Ib is the structurally relevant component of the GP Ib-IX complex contributing to metastasis. Our results support the hypothesis that platelet GP Ib-IX functions that support normal hemostasis or pathologic thrombosis also contribute to tumor malignancy. | ||
| 540 | |a Copyright 2007 The National Academy of Sciences of the United States of America | ||
| 650 | 4 | |a Adhesion | |
| 650 | 4 | |a Tumor | |
| 650 | 4 | |a Hemostasis | |
| 650 | 4 | |a Knockout | |
| 650 | 4 | |a Melanoma | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Platelets | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Tumors | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Cancer |x Metastasis | |
| 650 | 4 | |a Health sciences |x Health care industry |x Medical practice |x General practice | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Receptors | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Hematologic diseases |x Thrombosis | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x System physiology |x Cardiovascular physiology |x Blood circulation |x Hemostasis | |
| 650 | 4 | |a Mathematics |x Applied mathematics |x Statistics |x Applied statistics |x Descriptive statistics |x Central tendencies |x Statistical median | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood |x Blood cells |x Platelets | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Tumors | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Neoplasia |x Cancer |x Metastasis | |
| 650 | 4 | |a Health sciences |x Health care industry |x Medical practice |x General practice | |
| 650 | 4 | |a Biological sciences |x Biology |x Zoology |x Animals |x Mammals |x Rodents |x Mice | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x Body composition |x Body fluids |x Blood | |
| 650 | 4 | |a Physical sciences |x Chemistry |x Chemical compounds |x Chemicals |x Polymers |x Biopolymers |x Proteins |x Receptors | |
| 650 | 4 | |a Health sciences |x Medical conditions |x Diseases |x Hematologic diseases |x Thrombosis | |
| 650 | 4 | |a Biological sciences |x Biology |x Physiology |x System physiology |x Cardiovascular physiology |x Blood circulation |x Hemostasis | |
| 650 | 4 | |a Mathematics |x Applied mathematics |x Statistics |x Applied statistics |x Descriptive statistics |x Central tendencies |x Statistical median | |
| 655 | 4 | |a research-article | |
| 700 | 1 | |a Zuka, Masahiko |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jungling |e verfasserin |4 aut | |
| 700 | 1 | |a Russell, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Dent, Judith |e verfasserin |4 aut | |
| 700 | 1 | |a Guerrero, José A. |e verfasserin |4 aut | |
| 700 | 1 | |a Forsyth, Jane |e verfasserin |4 aut | |
| 700 | 1 | |a Maruszak, Brigid |e verfasserin |4 aut | |
| 700 | 1 | |a Gartner, T. Kent |e verfasserin |4 aut | |
| 700 | 1 | |a Felding-Habermann, Brunhilde |e verfasserin |4 aut | |
| 700 | 1 | |a Ware, Jerry |e verfasserin |4 aut | |
| 773 | 1 | 8 | |g volume:104 |g year:2007 |g number:21 |g pages:9024-9028 |
| 856 | 4 | 0 | |u https://www.jstor.org/stable/25427792 |3 Volltext |
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