|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
JST048968900 |
| 003 |
DE-627 |
| 005 |
20240125163720.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
150324s2005 xx |||||o 00| ||eng c |
| 035 |
|
|
|a (DE-627)JST048968900
|
| 035 |
|
|
|a (JST)30077812
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Rubin, Steven A.
|e verfasserin
|4 aut
|
| 245 |
1 |
4 |
|a The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study
|
| 264 |
|
1 |
|c 2005
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a Computermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a Online-Ressource
|b cr
|2 rdacarrier
|
| 520 |
|
|
|a Because of the highly neurotropic and neurovirulent properties of wild-type mumps viruses, most national regulatory organizations require neurovirulence testing of virus seeds used in the production of mumps vaccines. Such testing has historically been performed in monkeys; however, some data suggest that testing in monkeys does not necessarily discriminate among the relative neurovirulent risks of mumps virus strains. To address this problem, a collaborative study was initiated by the National Institute for Biological Standards and Control in the United Kingdom and the Food and Drug Administration in the United States, to test a novel rat-based mumps virus neurovirulence safety test. Results indicate that the assay correctly assesses the neurovirulence potential of mumps viruses in humans and is robust and reproducible.
|
| 540 |
|
|
|a Copyright 2005 Infectious Diseases Society of America
|
| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|
| 650 |
|
4 |
|a Health sciences
|x Medical treatment
|x Biological therapy
|x Immunotherapy
|x Immunization
|x Vaccination
|
| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Paramyxoviridae
|x Mumps virus
|
| 650 |
|
4 |
|a Health sciences
|x Medical treatment
|x Biological therapy
|x Immunotherapy
|x Immunization
|x Vaccination
|x Viral vaccines
|x Mumps vaccines
|
| 650 |
|
4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Infectious diseases
|x Viral diseases
|x RNA viral infections
|x Paramyxoviridae infections
|x Mumps
|
| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Cultured cells
|x Cell lines
|x Vero cells
|
| 650 |
|
4 |
|a Health sciences
|x Medical treatment
|x Biological therapy
|x Immunotherapy
|x Immunization
|x Vaccination
|x Combined vaccines
|x Measels mumps rubella vaccine
|
| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mammals
|x Rodents
|x Rats
|
| 650 |
|
4 |
|a Health sciences
|x Medical treatment
|x Biological therapy
|x Immunotherapy
|x Immunization
|x Vaccination
|x Attenuated vaccines
|
| 650 |
|
4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Nervous system diseases
|x Central nervous system diseases
|x Meningitis
|x Aseptic meningitis
|x Major Articles and Brief Reports
|x Viruses
|
| 655 |
|
4 |
|a research-article
|
| 700 |
1 |
|
|a Afzal, Muhammad A.
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Powell, Caroline L.
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bentley, Maureen L.
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Auda, Ghazi R.
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Taffs, Rolf E.
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Carbone, Kathryn M.
|e verfasserin
|4 aut
|
| 773 |
1 |
8 |
|g volume:191
|g year:2005
|g number:7
|g pages:1123-1128
|
| 856 |
4 |
0 |
|u https://www.jstor.org/stable/30077812
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a GBV_JST
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 191
|j 2005
|e 7
|h 1123-1128
|
