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150324s1993 xx |||||o 00| ||eng c |
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|a (DE-627)JST048898058
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|a (JST)30113690
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Saltini, Cesare
|e verfasserin
|4 aut
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|a Early Abnormalities of the Antibody Response against Mycobacterium Tuberculosis in Human Immunodeficiency Virus Infection
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|c 1993
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
|b c
|2 rdamedia
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|a Online-Ressource
|b cr
|2 rdacarrier
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|a Among human immunodeficiency virus (HlV)-infected persons, those who react against purified protein derivative (PPD) have higher risk of tuberculosis. Since PPD testing has limited predictive power in HIV-positive populations, new markers of antituberculous immunity were sought by analyzing antibodies to Mycobacterium tuberculosis antigens (PPD and its fraction A60) in 102 HIV-positive subjects, some PPD-positive and some PPD-negative, and in 23 HIVpositive tuberculosis patients. ELISA and Western blotting were used. Forty HIV-negative healthy subjects and 40 HIV-negative tuberculosis patients were evaluated as controls. While all those HIV-negative and PPD-positive had IgG antibodies recognizing the 38-, 28-, and 19-kDa M tuberculosis antigens, only 260Zo of those HIV-positive and PPD-positive (all with<400 CD⁺ cells/mm) and none of the HIV-positive tuberculosis patients recognized them, indicating that the lack of IgG against those antigens, in the presence of a specific IgM response, is a marker of immunodeficiency.
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|a Copyright 1993 The University of Chicago
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Infections
|x Bacterial infections
|x Gram positive bacterial infections
|x Tuberculosis
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Immunology
|x Immune system
|x Immune response
|x Adaptive immunity
|x Active immunity
|x Humoral immunity
|x Antibodies
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Bacteriology
|x Bacteria
|x Gram positive bacteria
|x Actinobacteria
|x Actinomycetales
|x Mycobacterium
|x Mycobacterium tuberculosis
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Immunology
|x Immune system
|x Immune response
|x Adaptive immunity
|x Active immunity
|x Humoral immunity
|x Antigens
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| 650 |
|
4 |
|a Health sciences
|x Medical sciences
|x Immunology
|x Immune system
|x Immune response
|x Adaptive immunity
|x Active immunity
|x Humoral immunity
|x Antigens
|x Bacterial antigens
|x Tuberculin
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Physiology
|x Body composition
|x Body fluids
|x Blood
|x Blood cells
|x Leukocytes
|x Mononuclear leukocytes
|x Lymphocytes
|x T lymphocytes
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Immune system diseases
|x AIDS
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x Oncogenic viruses
|x Retroviridae
|x Lentivirus
|x Primate lentiviruses
|x HIV
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Immunology
|x Immunologic techniques
|x Immunoassay
|x Enzyme linked immunosorbent assay
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Infections
|x Major Articles
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| 655 |
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4 |
|a research-article
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|a Amicosante, Massimo
|e verfasserin
|4 aut
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|a Girardi, Enrico
|e verfasserin
|4 aut
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|a Antonucci, Giorgio
|e verfasserin
|4 aut
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|a Ippolito, Giuseppe
|e verfasserin
|4 aut
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| 700 |
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|a Ameglio, Franco
|e verfasserin
|4 aut
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| 700 |
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|a Monno, Laura
|e verfasserin
|4 aut
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| 700 |
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|a Congedo, Pierpaolo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Angarano, Gioacchino
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Babudieri, Sergio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guaraldi, Giovanni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Visco, Giuseppe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Piccolella, Enza
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Paone, Gregorino
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pallotta, Giovanni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bisetti, Alberto
|e verfasserin
|4 aut
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| 773 |
1 |
8 |
|g volume:168
|g year:1993
|g number:6
|g pages:1409-1414
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| 856 |
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|u https://www.jstor.org/stable/30113690
|3 Volltext
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|a GBV_USEFLAG_A
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|a GBV_JST
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|a AR
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| 952 |
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|d 168
|j 1993
|e 6
|h 1409-1414
|
