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|a (JST)30086732
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|a DE-627
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|a eng
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|a Belser, Jessica A.
|e verfasserin
|4 aut
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|a DAS181, a Novel Sialidase Fusion Protein, Protects Mice from Lethal Avian Influenza H5N1 Virus Infection
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a Computermedien
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|a Online-Ressource
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|a Increasing resistance to currently available influenza antivirals highlights the need to develop alternate approaches for the prevention and/or treatment of influenza. DAS 181 (Fludase), a novel sialidase fusion protein that enzymatically removes sialic acids on respiratory epithelium, exhibits potent antiviral activity against influenza A and B viruses. Here, we use a mouse model to evaluate the efficacy of DAS181 treatment against a highly pathogenic avian influenza H5N1 virus. When used to treat mice daily beginning 1 day before infection with A/Vietnam/1203/2004(H5N1) virus, DAS181 treatment at 1 mg/kg/day protected 100% of mice from fatal disease, prevented viral dissemination to the brain, and effectively blocked infection in 70% of mice. DAS181 at 1 mg/kg/day was also effective therapeutically, conferring enhanced survival of H5N1 virus-challenged mice when treatment was begun 72 h after infection. This notable antiviral activity underscores the potential utility of DAS 181 as a new class of drug that is effective against influenza viruses with pandemic potential.
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|a Copyright 2007 Infectious Diseases Society of America
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Infections
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Orthomyxoviridae
|x Influenza A virus
|x H5N1 subtype influenza A virus
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Pharmaceutics
|x Pharmaceutical preparations
|x Medications
|x Antiinfectives
|x Antivirals
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Orthomyxoviridae
|x Influenza A virus
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Pharmacology
|x Clinical pharmacology
|x Pharmacokinetics
|x Dosage
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Orthomyxoviridae
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mammals
|x Rodents
|x Mice
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| 650 |
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4 |
|a Health sciences
|x Medical sciences
|x Immunology
|x Immune system
|x Immune response
|x Adaptive immunity
|x Active immunity
|x Humoral immunity
|x Antibodies
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Physiology
|x Body composition
|x Body weight
|x Weight loss
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Infections
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Orthomyxoviridae
|x Influenza A virus
|x H5N1 subtype influenza A virus
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
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| 650 |
|
4 |
|a Health sciences
|x Medical sciences
|x Pharmaceutics
|x Pharmaceutical preparations
|x Medications
|x Antiinfectives
|x Antivirals
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Orthomyxoviridae
|x Influenza A virus
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| 650 |
|
4 |
|a Health sciences
|x Medical sciences
|x Pharmacology
|x Clinical pharmacology
|x Pharmacokinetics
|x Dosage
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Microbiology
|x Microorganisms
|x Viruses
|x RNA viruses
|x Orthomyxoviridae
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Mammals
|x Rodents
|x Mice
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| 650 |
|
4 |
|a Health sciences
|x Medical sciences
|x Immunology
|x Immune system
|x Immune response
|x Adaptive immunity
|x Active immunity
|x Humoral immunity
|x Antibodies
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Physiology
|x Body composition
|x Body weight
|x Weight loss
|x Major Articles and Brief Reports
|x Viruses
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| 655 |
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4 |
|a research-article
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| 700 |
1 |
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|a Lu, Xiuhua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Szretter, Kristy J.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, Xiaoping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aschenbrenner, Laura M.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Alice
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hawley, Stephen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Do Hyong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Malakhov, Michael P.
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Mang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fang, Fang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Katz, Jacqueline M.
|e verfasserin
|4 aut
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| 773 |
1 |
8 |
|g volume:196
|g year:2007
|g number:10
|g pages:1493-1499
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|u https://www.jstor.org/stable/30086732
|3 Volltext
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|a GBV_USEFLAG_A
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|a GBV_JST
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|d 196
|j 2007
|e 10
|h 1493-1499
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