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|a (JST)40384051
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|a eng
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|a Wang, Tao
|e verfasserin
|4 aut
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| 245 |
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|a TOR-Mediated Autophagy Regulates Cell Death in "Drosophila" Neurodegenerative Disease
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|c 2009
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|a Text
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|a Target of rapamycin (TOR) signaling is a regulator of cell growth. TOR activity can also enhance cell death, and the TOR inhibitor rapamycin protects cells against proapoptotic stimuli. Autophagy, which can protect against cell death, is negatively regulated by TOR, and disruption of autophagy by mutation of Atg5 or Atg7 can lead to neurodegeneration. However, the implied functional connection between TOR signaling, autophagy, and cell death or degeneration has not been rigorously tested. Using the Drosophila melanogoster visual system, we show in this study that hyperactivation of TOR leads to photoreceptor cell death in an age-and light-dependent manner and that this is because of TOR's ability to suppress autophagy. We also find that genetically inhibiting TOR or inducing autophagy suppresses cell death in Drosophila models of Huntington's disease and phospholipase C (norpA)-mediated retinal degeneration. Thus, our data indicate that TOR induces cell death by suppressing autophagy and provide direct genetic evidence that autophagy alleviates cell death in several common types of neurodegenerative disease.
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| 650 |
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|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cell physiology
|x Cell death
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Cellular receptors
|x Sensory receptor cells
|x Photoreceptors
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Neurons
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|a Health sciences
|x Medical sciences
|x Medical research
|x Biomedical research
|x Disease models
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| 650 |
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|a Health sciences
|x Medical conditions
|x Diseases
|x Nervous system diseases
|x Neurodegenerative diseases
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Eye diseases
|x Retinal diseases
|x Retinal degeneration
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Invertebrates
|x Arthropods
|x Insects
|x Flies
|x Fruit flies
|x Drosophila
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Nervous system diseases
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cell physiology
|x Cell growth
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animal anatomy
|x Animal morphology
|x Insect morphology
|x Compound eyes
|x Ommatidia
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| 650 |
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4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cell physiology
|x Cell death
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Cellular receptors
|x Sensory receptor cells
|x Photoreceptors
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cells
|x Neurons
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| 650 |
|
4 |
|a Health sciences
|x Medical sciences
|x Medical research
|x Biomedical research
|x Disease models
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| 650 |
|
4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Nervous system diseases
|x Neurodegenerative diseases
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| 650 |
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4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Eye diseases
|x Retinal diseases
|x Retinal degeneration
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animals
|x Invertebrates
|x Arthropods
|x Insects
|x Flies
|x Fruit flies
|x Drosophila
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| 650 |
|
4 |
|a Health sciences
|x Medical conditions
|x Diseases
|x Nervous system diseases
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Cytology
|x Cell biology
|x Cell physiology
|x Cell growth
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| 650 |
|
4 |
|a Biological sciences
|x Biology
|x Zoology
|x Animal anatomy
|x Animal morphology
|x Insect morphology
|x Compound eyes
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|a research-article
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| 700 |
1 |
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|a Lao, Uyen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Edgar, Bruce A.
|e verfasserin
|4 aut
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| 773 |
1 |
8 |
|g volume:186
|g year:2009
|g number:5
|g pages:703-711
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|u https://www.jstor.org/stable/40384051
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|d 186
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|h 703-711
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