Elevated resting heart rates are a risk factor for mortality among patients with coronavirus disease 2019 in Wuhan, China
Background: We evaluated the association between higher resting heart rates (RHRs) and adverse events in COVID-19 patients. Methods: One hundred and thirty-six patients with laboratory-confirmed COVID-19 were admitted. Outcomes of patients with different RHRs were compared. Results: Twenty-nine patients had RHRs of <80 bpm (beat per min), 85 had 80–99 bpm and 22 had ≥100 bpm as tachycardia. Those with higher RHRs had lower pulse oxygen saturation ($ SpO_{2} $) and higher temperatures, and there was a higher proportion of men upon admission (all P < 0.05). Patients with higher RHRs showed higher white blood cell counts and D-dimer, cardiac troponin I (TnI), N-terminal pro-B-type natriuretic peptide and hypersensitive C-reactive protein levels, but lower albumin levels (all P < 0.05) after admission. During follow-up, 26 patients died (mortality rate, 19.1%). The mortality rate was significantly higher among patients with tachycardia than among the moderate and low RHR groups (all P < 0.001). Kaplan–Meier survival curves showed that the risks of death and ventilation use increased for patients with tachycardia (P < 0.001). Elevated RHR as a continuous variable and a mean RHR as tachycardia were independent risk factors for mortality and ventilator use (all P < 0.05) in the multivariable adjusted Cox proportional hazards regression model. Conclusions: Elevated average RHRs during the first 3 days of hospitalisation were associated with adverse outcomes in COVID-19 patients. Average RHRs as tachycardia can independently predict all-cause mortality..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
|---|---|
| Enthalten in: |
Journal of translational internal medicine - 9(2021), 4 vom: 31. Dez., Seite 285-293 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jin, Han [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
© 2021 Han Jin et al., published by Sciendo |
|---|
| doi: |
10.2478/jtim-2021-0042 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
GRUY008596530 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | GRUY008596530 | ||
| 003 | DE-627 | ||
| 005 | 20230813123329.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230813s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2478/jtim-2021-0042 |2 doi | |
| 035 | |a (DE-627)GRUY008596530 | ||
| 035 | |a (DE-B1597)jtim-2021-0042-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Jin, Han |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Elevated resting heart rates are a risk factor for mortality among patients with coronavirus disease 2019 in Wuhan, China |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © 2021 Han Jin et al., published by Sciendo | ||
| 520 | |a Background: We evaluated the association between higher resting heart rates (RHRs) and adverse events in COVID-19 patients. Methods: One hundred and thirty-six patients with laboratory-confirmed COVID-19 were admitted. Outcomes of patients with different RHRs were compared. Results: Twenty-nine patients had RHRs of <80 bpm (beat per min), 85 had 80–99 bpm and 22 had ≥100 bpm as tachycardia. Those with higher RHRs had lower pulse oxygen saturation ($ SpO_{2} $) and higher temperatures, and there was a higher proportion of men upon admission (all P < 0.05). Patients with higher RHRs showed higher white blood cell counts and D-dimer, cardiac troponin I (TnI), N-terminal pro-B-type natriuretic peptide and hypersensitive C-reactive protein levels, but lower albumin levels (all P < 0.05) after admission. During follow-up, 26 patients died (mortality rate, 19.1%). The mortality rate was significantly higher among patients with tachycardia than among the moderate and low RHR groups (all P < 0.001). Kaplan–Meier survival curves showed that the risks of death and ventilation use increased for patients with tachycardia (P < 0.001). Elevated RHR as a continuous variable and a mean RHR as tachycardia were independent risk factors for mortality and ventilator use (all P < 0.05) in the multivariable adjusted Cox proportional hazards regression model. Conclusions: Elevated average RHRs during the first 3 days of hospitalisation were associated with adverse outcomes in COVID-19 patients. Average RHRs as tachycardia can independently predict all-cause mortality. | ||
| 700 | 1 | |a Yang, Shengwen |4 aut | |
| 700 | 1 | |a Yang, Fan |4 aut | |
| 700 | 1 | |a Zhang, Long |4 aut | |
| 700 | 1 | |a Weng, Haoyu |4 aut | |
| 700 | 1 | |a Liu, Shengcong |4 aut | |
| 700 | 1 | |a Fan, Fangfang |4 aut | |
| 700 | 1 | |a Li, Haichao |4 aut | |
| 700 | 1 | |a Zheng, Xizi |4 aut | |
| 700 | 1 | |a Yang, Hongyu |4 aut | |
| 700 | 1 | |a Zhang, Yan |4 aut | |
| 700 | 1 | |a Zhou, Jing |4 aut | |
| 700 | 1 | |a Li, Jianping |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of translational internal medicine |d Sciendo, 2013 |g 9(2021), 4 vom: 31. Dez., Seite 285-293 |h Online-Ressource |w (DE-627)GRUY000294934 |w (DE-600)2861892-0 |w (DE-576)474043371 |x 2224-4018 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2021 |g number:4 |g day:31 |g month:12 |g pages:285-293 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.2478/jtim-2021-0042 |z kostenfrei |3 Volltext |
| 912 | |a GBV_GRUY | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 2021 |e 4 |b 31 |c 12 |h 285-293 | ||