Preparation method of ocean polysaccharide special-shaped gel drug-loaded microspheres simulating pitaya seed structure
The invention discloses a preparation method of ocean polysaccharide special-shaped gel drug-loaded microspheres simulating a pitaya seed structure. The preparation method comprises the following steps: (1) preparing a mixed solution of adhesive ocean polysaccharide molecules and whey protein; (2) adding a water-soluble drug into the mixed solution obtained in the step (1), uniformly stirring, and standing in a refrigerator to obtain a water-soluble drug/marine polysaccharide/whey protein solution; or mixing the material obtained in the step (1) with an ethanol/soybean lecithin solution of a fat-soluble drug, adding a surfactant, and homogenizing to obtain an oil-in-water emulsion; and (3) slowly dripping the material obtained in the step (2) into an ionic cross-linking agent solution in a continuous stirring state under a negative pressure condition for cross-linking, then soaking in an enteric coating solution, and finally drying to obtain the pitaya seed structure-imitated marine polysaccharide special-shaped gel drug-loaded microspheres. The drug-loaded microspheres prepared by the invention are easier to adhere to intestinal tracts, and the drug action time is prolonged, so that the bioavailability of oral drugs is improved..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 05. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LIN LING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-05, Last update posted on www.tib.eu: 2024-03-04, Last updated: 2024-03-08 |
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| Patentnummer: |
CN117159502 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019340184 |
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| 245 | 1 | 0 | |a Preparation method of ocean polysaccharide special-shaped gel drug-loaded microspheres simulating pitaya seed structure |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-12-05, Last update posted on www.tib.eu: 2024-03-04, Last updated: 2024-03-08 | ||
| 520 | |a The invention discloses a preparation method of ocean polysaccharide special-shaped gel drug-loaded microspheres simulating a pitaya seed structure. The preparation method comprises the following steps: (1) preparing a mixed solution of adhesive ocean polysaccharide molecules and whey protein; (2) adding a water-soluble drug into the mixed solution obtained in the step (1), uniformly stirring, and standing in a refrigerator to obtain a water-soluble drug/marine polysaccharide/whey protein solution; or mixing the material obtained in the step (1) with an ethanol/soybean lecithin solution of a fat-soluble drug, adding a surfactant, and homogenizing to obtain an oil-in-water emulsion; and (3) slowly dripping the material obtained in the step (2) into an ionic cross-linking agent solution in a continuous stirring state under a negative pressure condition for cross-linking, then soaking in an enteric coating solution, and finally drying to obtain the pitaya seed structure-imitated marine polysaccharide special-shaped gel drug-loaded microspheres. The drug-loaded microspheres prepared by the invention are easier to adhere to intestinal tracts, and the drug action time is prolonged, so that the bioavailability of oral drugs is improved. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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