Injectable hydrogel as well as preparation method and application thereof
The invention discloses injectable hydrogel and a preparation method and application thereof.The preparation method comprises the steps that a solution A and a solution B which can obtain the hydrogel through mixing are provided, and the solution A comprises the steps that polydopamine is dispersed in a solution of recombinant collagen containing grafted hydrazide groups to obtain the solution A; the solution B is prepared by dispersing Se and Mg co-doped hydrophilic hydroxyapatite into a solution containing oxidized chondroitin sulfate, so that the solution B is obtained. The injectable hydrogel disclosed by the invention effectively combines the photothermal effect of polydopamine, the tumor inhibition and cell growth promotion characteristics of selenium and magnesium doped hydroxyapatite, the good biocompatibility of chondroitin sulfate and the cell growth promotion characteristics of recombinant collagen, realizes osteosarcoma ablation-bone tissue repair through treatment under a light photothermal condition, and has the advantages of high biocompatibility, high biocompatibility and high biocompatibility. The device has the characteristics of rapidly ablating tumors and realizing bone defect repair..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 05. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HUI JUNFENG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-05, Last update posted on www.tib.eu: 2024-03-04, Last updated: 2024-03-08 |
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| Patentnummer: |
CN117159795 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019323794 |
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| 245 | 1 | 0 | |a Injectable hydrogel as well as preparation method and application thereof |
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| 520 | |a The invention discloses injectable hydrogel and a preparation method and application thereof.The preparation method comprises the steps that a solution A and a solution B which can obtain the hydrogel through mixing are provided, and the solution A comprises the steps that polydopamine is dispersed in a solution of recombinant collagen containing grafted hydrazide groups to obtain the solution A; the solution B is prepared by dispersing Se and Mg co-doped hydrophilic hydroxyapatite into a solution containing oxidized chondroitin sulfate, so that the solution B is obtained. The injectable hydrogel disclosed by the invention effectively combines the photothermal effect of polydopamine, the tumor inhibition and cell growth promotion characteristics of selenium and magnesium doped hydroxyapatite, the good biocompatibility of chondroitin sulfate and the cell growth promotion characteristics of recombinant collagen, realizes osteosarcoma ablation-bone tissue repair through treatment under a light photothermal condition, and has the advantages of high biocompatibility, high biocompatibility and high biocompatibility. The device has the characteristics of rapidly ablating tumors and realizing bone defect repair. | ||
| 650 | 4 | |a A61L: Methods or apparatus for sterilising materials or objects in general; disinfection, sterilisation, or deodorisation of air; chemical aspects of bandages, dressings, absorbent pads, or surgical articles; materials for bandages, dressings, absorbent pads, or surgical articles (preservation of bodies or disinfecting characterised by the agent employed a01n;preserving, e.g. sterilising, food or foodstuffs a23;preparations for medical, dental or toilet purposes a61k) | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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