HUMAN CYTOMEGALOVIRUS ANTIGEN EPITOPE CHIMERIC PEPTIDE AND USE THEREOF
The present invention provides a human cytomegalovirus antigen epitope chimeric peptide and a use thereof. An amino acid sequence of the human cytomegalovirus antigen epitope chimeric peptide is selected from SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3 or SEQ ID NO.4. On the basis of optimized and screened HCMV overlapping T cell epitopes, Th cell epitopes and B cell epitopes, the present invention obtains four HCMV dominant antigen epitope chimeric peptides. Vaccines containing said epitope chimeric peptides have good immunogenicity and safety in mouse models, and can induce humoral and cellular immune responses in a short period of time..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 22. Feb. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WANG BIN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-02-22, Last update posted on www.tib.eu: 2024-03-07, Last updated: 2024-03-08 |
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| Patentnummer: |
WO2024037005 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019317719 |
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| 520 | |a The present invention provides a human cytomegalovirus antigen epitope chimeric peptide and a use thereof. An amino acid sequence of the human cytomegalovirus antigen epitope chimeric peptide is selected from SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3 or SEQ ID NO.4. On the basis of optimized and screened HCMV overlapping T cell epitopes, Th cell epitopes and B cell epitopes, the present invention obtains four HCMV dominant antigen epitope chimeric peptides. Vaccines containing said epitope chimeric peptides have good immunogenicity and safety in mouse models, and can induce humoral and cellular immune responses in a short period of time. | ||
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