COMPOUNDS
The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus:wherein -R<sup>15</sup> is a group:and -R<sup>16</sup> is hydrogen; -R<sup>17</sup> is hydrogen; -L- is a covalent bond or methylene; and -Ar is optionally substituted aryl. The groups -X-, -R<sup>1</sup>, -R<sup>2</sup>, -R<sup>3</sup>, -R<sup>4</sup>, and -R<sup>8</sup> are as defined herein..
| Medienart: |
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 07. Feb. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
BROWN PAMELA [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-02-07, Last update posted on www.tib.eu: 2024-02-27, Last updated: 2024-03-01 |
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| Patentnummer: |
EP4316504 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019205732 |
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| 520 | |a The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus:wherein -R<sup>15</sup> is a group:and -R<sup>16</sup> is hydrogen; -R<sup>17</sup> is hydrogen; -L- is a covalent bond or methylene; and -Ar is optionally substituted aryl. The groups -X-, -R<sup>1</sup>, -R<sup>2</sup>, -R<sup>3</sup>, -R<sup>4</sup>, and -R<sup>8</sup> are as defined herein. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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