Anti-inflammatory cartilage regeneration promoting material as well as preparation method and application thereof
The invention discloses an anti-inflammatory cartilage regeneration promoting material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The anti-inflammatory cartilage regeneration promoting material comprises a PLGA (50: 50) polymeric high polymer material and a huperzine A derivative dimer loaded on the PLGA polymeric high polymer material through 3D printing. The invention further provides application of the anti-inflammatory cartilage regeneration promoting material in preparation of drugs for resisting inflammation, protecting cartilage or promoting cartilage regeneration. The PLGA/A10E scaffold disclosed by the invention has good biocompatibility, and a degradation release liquid of the PLGA/A10E scaffold can effectively promote cartilage precursor cells to differentiate into cartilage and increase formation of a cartilage collagen matrix and cartilage proteoglycan. The PLGA/A10E stent in-vitro degradation liquid can promote the expression of SOX9 under a non-inflammatory condition; the expression of MMP-13 can be inhibited under the condition of LPS-mediated inflammation, so that the synthesis of a cartilage matrix is promoted, and the degradation of the cartilage matrix is inhibited..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 01. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WANG XINLUAN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-01, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN117138108 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019189850 |
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| 520 | |a The invention discloses an anti-inflammatory cartilage regeneration promoting material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The anti-inflammatory cartilage regeneration promoting material comprises a PLGA (50: 50) polymeric high polymer material and a huperzine A derivative dimer loaded on the PLGA polymeric high polymer material through 3D printing. The invention further provides application of the anti-inflammatory cartilage regeneration promoting material in preparation of drugs for resisting inflammation, protecting cartilage or promoting cartilage regeneration. The PLGA/A10E scaffold disclosed by the invention has good biocompatibility, and a degradation release liquid of the PLGA/A10E scaffold can effectively promote cartilage precursor cells to differentiate into cartilage and increase formation of a cartilage collagen matrix and cartilage proteoglycan. The PLGA/A10E stent in-vitro degradation liquid can promote the expression of SOX9 under a non-inflammatory condition; the expression of MMP-13 can be inhibited under the condition of LPS-mediated inflammation, so that the synthesis of a cartilage matrix is promoted, and the degradation of the cartilage matrix is inhibited. | ||
| 650 | 4 | |a mas | |
| 650 | 4 | |a A61L: Methods or apparatus for sterilising materials or objects in general; disinfection, sterilisation, or deodorisation of air; chemical aspects of bandages, dressings, absorbent pads, or surgical articles; materials for bandages, dressings, absorbent pads, or surgical articles (preservation of bodies or disinfecting characterised by the agent employed a01n;preserving, e.g. sterilising, food or foodstuffs a23;preparations for medical, dental or toilet purposes a61k) | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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| 650 | 4 | |a B33Y: Additive manufacturing, i.e. manufacturing of three-dimensional [3d] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3d printing, stereolithography or selective laser sintering | |
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