Preparation method, product and application of chitosan thioketal active oxygen scavenging hydrogel
The invention discloses a preparation method of chitosan thioketal active oxygen scavenging hydrogel as well as a product and application of the chitosan thioketal active oxygen scavenging hydrogel, firstly, thioketal chitosan is prepared by adopting amidation reaction, and then the hydrogel is prepared. The hydrogel prepared by the preparation method disclosed by the invention shows good injectability, and compared with chitosan, the thioketal modified hydrogel has a better removal effect on NO. Compared with corresponding chitosan, the low-viscosity modified thioketal chitosan hydrogel has an optimal antibacterial effect due to good water solubility, the antibacterial rate of the low-viscosity modified thioketal chitosan hydrogel reaches (99.93 +/-0.105)%, the antibacterial rate of the high-viscosity modified chitosan hydrogel reaches (91.57 +/-10.813)%, and the inhibition rate of the medium-viscosity modified chitosan is (67.09 +/-10.426)%. The thioketal chitosan is expected to be applied to new medicinal dosage forms and medical biological materials such as chronic wound gel, antibacterial and anti-reactive oxygen gel dressings and the like..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 01. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
QIU LIPENG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-01, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN117143362 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019149662 |
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| LEADER | 01000naa a22002652 4500 | ||
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| 245 | 1 | 0 | |a Preparation method, product and application of chitosan thioketal active oxygen scavenging hydrogel |
| 264 | 1 | |c 2023 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-12-01, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 | ||
| 520 | |a The invention discloses a preparation method of chitosan thioketal active oxygen scavenging hydrogel as well as a product and application of the chitosan thioketal active oxygen scavenging hydrogel, firstly, thioketal chitosan is prepared by adopting amidation reaction, and then the hydrogel is prepared. The hydrogel prepared by the preparation method disclosed by the invention shows good injectability, and compared with chitosan, the thioketal modified hydrogel has a better removal effect on NO. Compared with corresponding chitosan, the low-viscosity modified thioketal chitosan hydrogel has an optimal antibacterial effect due to good water solubility, the antibacterial rate of the low-viscosity modified thioketal chitosan hydrogel reaches (99.93 +/-0.105)%, the antibacterial rate of the high-viscosity modified chitosan hydrogel reaches (91.57 +/-10.813)%, and the inhibition rate of the medium-viscosity modified chitosan is (67.09 +/-10.426)%. The thioketal chitosan is expected to be applied to new medicinal dosage forms and medical biological materials such as chronic wound gel, antibacterial and anti-reactive oxygen gel dressings and the like. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C08J: Working-up; general processes of compounding; after-treatment not covered by subclasses c08b, c08c, c08f, c08g or c08h (working, e.g. shaping, of plastics b29) | |
| 650 | 4 | |a che | |
| 650 | 4 | |a C08B: Polysaccharides; derivatives thereof (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages c07h;fermentation or enzyme-using processes c12p0019000000;production of cellulose d21) | |
| 650 | 4 | |a C08L: Compositions of macromolecular compounds (compositions based on polymerisable monomers c08f, c08g;artificial filaments or fibres d01f;textile treating compositions d06) | |
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