Protein and vaccine for resisting SARS-CoV-2 infection
The invention relates to a protein and a vaccine for resisting SARS-CoV-2 infection, and belongs to the field of medicines. In order to solve the problem of lack of effective prevention and treatment drugs for SARS-CoV-2 infection, especially SARS-CoV-2 mutant virus infection, the invention provides a protein for resisting SARS-CoV-2 infection, and the protein is a tripolymer spontaneously formed by an RBD sequence in an S protein of SARS-CoV-2 and heptapeptide repeat regions HR1 and HR2; wherein the RBD sequence is an amino acid sequence which is the same as 320-545 amino acids in S protein of SARS-CoV-2 or has 97% or more of homology with the 320-545 amino acids and has the same or similar biological activity. The invention also provides a vaccine for resisting SARS-CoV-2 infection, which helps a host to resist coronavirus infection, and especially has a relatively good prevention and treatment effect on an Ombrag mutant strain..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 28. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WEI XIAYU [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-28, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN117126297 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019139500 |
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| 520 | |a The invention relates to a protein and a vaccine for resisting SARS-CoV-2 infection, and belongs to the field of medicines. In order to solve the problem of lack of effective prevention and treatment drugs for SARS-CoV-2 infection, especially SARS-CoV-2 mutant virus infection, the invention provides a protein for resisting SARS-CoV-2 infection, and the protein is a tripolymer spontaneously formed by an RBD sequence in an S protein of SARS-CoV-2 and heptapeptide repeat regions HR1 and HR2; wherein the RBD sequence is an amino acid sequence which is the same as 320-545 amino acids in S protein of SARS-CoV-2 or has 97% or more of homology with the 320-545 amino acids and has the same or similar biological activity. The invention also provides a vaccine for resisting SARS-CoV-2 infection, which helps a host to resist coronavirus infection, and especially has a relatively good prevention and treatment effect on an Ombrag mutant strain. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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