Application of 1, 5-diphenylpent-1, 4-diene-3-ketone compound in preparation of anti-schistosome drugs
The invention belongs to the technical field of medicines, and particularly relates to application of a 1, 5-diphenylpent-1, 4-diene-3-ketone compound in preparation of an anti-schistosome medicine. The 1, 5-diphenylpent-1, 4-diene-3-ketone compound has a structure as shown in a formula 1 which is described in the specification. The 1, 5-diphenylpent-1, 4-diene-3-ketone compound with the structure as shown in the formula 1 provided by the invention has an unsaturated carbonyl structural unit (Michael receptor unit) and a benzene ring structure, and a middle chain segment, connected with the Michael receptor unit, of the benzene ring structure is relatively short, so that the anti-schistosome activity of the compound is improved, the structural stability is enhanced, and the bioavailability is improved. Meanwhile, the 1, 5-diphenylpent-1, 4-diene-3-ketone compound provided by the invention is low in toxicity, can repair host liver injury caused by schistosome infection to a certain extent and reduce the degree of liver fibrosis, and has a strong protection effect on hosts..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 24. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
QIAN YIPING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-24, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN117100726 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019138865 |
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| 520 | |a The invention belongs to the technical field of medicines, and particularly relates to application of a 1, 5-diphenylpent-1, 4-diene-3-ketone compound in preparation of an anti-schistosome medicine. The 1, 5-diphenylpent-1, 4-diene-3-ketone compound has a structure as shown in a formula 1 which is described in the specification. The 1, 5-diphenylpent-1, 4-diene-3-ketone compound with the structure as shown in the formula 1 provided by the invention has an unsaturated carbonyl structural unit (Michael receptor unit) and a benzene ring structure, and a middle chain segment, connected with the Michael receptor unit, of the benzene ring structure is relatively short, so that the anti-schistosome activity of the compound is improved, the structural stability is enhanced, and the bioavailability is improved. Meanwhile, the 1, 5-diphenylpent-1, 4-diene-3-ketone compound provided by the invention is low in toxicity, can repair host liver injury caused by schistosome infection to a certain extent and reduce the degree of liver fibrosis, and has a strong protection effect on hosts. | ||
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